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Differential Contribution of Diabetes and the Ren2 Gene to Glomerular Pathology in Diabetic (mREN-2)27 Rats
Narrowing the scope of utility for (mREN-2)27 rats may help to create better methods for researching diabetic nephropathy. Laboratory Investigation (Source: Medscape Today Headlines)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
Longitudinal examination of cervical volume and vascularization changes during the antepartum and postpartum period using three-dimensional and power Doppler ultrasound
Journal of Perinatal Medicine 38 (5): 461-465 Abstract Objective: To assess longitudinally the changes in cervical volume and vascularization during the peripartum period using three-dimensional ultrasound (3D US) and power Doppler and to determine whether these measures change with gestational complications. Methods: Longitudinal measurements of cervical dimensions by transvaginal 3D US and power Doppler using the virtual organ computer-aided analysis program were performed at 11?14, 22?24, 32?34 weeks' gestation, and at 6 weeks' postpartum in 111 pregnant women. Comparisons were made between women who delivered at term (vs. preterm), nulliparous (vs. parous), with (vs. without) pre-eclampsia and those with (vs. without) gestational diabetes. Results: After establishing reference ...
Pcif1 modulates Pdx1 protein stability and pancreatic {beta} cell function and survival in mice
The homeodomain transcription factor pancreatic duodenal homeobox 1 (Pdx1) is a major mediator of insulin transcription and a key regulator of the β cell phenotype. Heterozygous mutations in PDX1 are associated with the development of diabetes in humans. Understanding how Pdx1 expression levels are controlled is therefore of intense interest in the study and treatment of diabetes. Pdx1 C terminus–interacting factor-1 (Pcif1, also known as SPOP) is a nuclear protein that inhibits Pdx1 transactivation. Here, we show that Pcif1 targets Pdx1 for ubiquitination and proteasomal degradation. Silencing of Pcif1 increased Pdx1 protein levels in cultured mouse β cells, and Pcif1 heterozygosity normalized Pdx1 protein levels in Pdx1+/– mouse islets, thereby increasing ...
How do organisms make dietary choices?
When given a choice, organisms will choose a diet that maintains a nutritional balance in tune with their needs. That choice, studied in fruit flies for the first time, is regulated by activity in a molecular pathway involved in aging, cancer and diabetes. Humans share the same molecular pathway. The study, the first to be done in a genetically tractable lab animal, could lead to treatments that would "reboot" metabolic pathways in individuals who are obese or suffer from diabetes. (Source: ScienceDaily Headlines)
Children who eat vended snack foods face chronic health problems, poor diet, study finds
School children who consume foods purchased in vending machines are more likely to develop poor diet quality -- and that may be associated with being overweight, obese or at risk for chronic health problems such as diabetes and coronary artery disease, according to new research. (Source: ScienceDaily Headlines)
An Economic Evaluation of Colesevelam when Added to Metformin-, Insulin- or Sulfonylurea-Based Therapies in Patients with Uncontrolled Type 2 Diabetes Mellitus
(Source: PharmacoEconomics)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
Factor Structure and Measurement Invariance of a 10-Item Decisional Balance Scale: Longitudinal and Subgroup Examination Within an Adult Diabetic Sample
(Source: Measurement in Physical Education and Exercise Science)
Frequent Reoccurrence of Hypoglycemia in a Type 2 Diabetic Patient with Insulin Antibodies
(Source: Molecular Diagnosis)
Dr Oz colon polyps raises question of "spontaneous disease" without cause
(NaturalNews) Dr Oz was recently found to have a precancerous colon polyp which was surgically removed. Following this experience, he appears to be surprised and confused about the origin of the condition, and he credits colonoscopy screening with saving his life.Dr Oz even seems to think he has a perfect health record, saying, "I have done everything right. I don't have any family history, and yet I'm high risk now." His personal physician, meanwhile, is implying that even though Dr Oz's "healthy" diet was perfect, it wasn't enough to prevent colon polyps, and therefore you might get them too. (And therefore everybody should get screened...)Dr Jonathan Lapook, went on to say "...no matter what you do, you can't totally eliminate your risk of developing this disease, which is expected to s...
Association of doctor specialty with diabetic patient risk of hospitalization due to diabetic ketoacidosis: a national population?based study in Taiwan
(Source: Journal of Evaluation in Clinical Practice)
Mild BNP may indicate LV dysfunction in diabetics
Dutch researchers report that slightly elevated B-type natriuretic peptide levels are associated with increased left ventricular mass and diastolic dysfunction in patients with Type 2 diabetes. (Source: MedWire News - Diabetes)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
Celebrating World Diabetes Day and preparing for the battles ahead
(Source: Diabetes Research and Clinical Practice)
Influence of Left Ventricular Dysfunction (Diastolic Versus Systolic) on Long-Term Prognosis in Patients With Versus Without Diabetes Mellitus Having Elective Peripheral Arterial Surgery
In conclusion, diabetic patients with PAD have an increased prevalence of isolated systolic and combined LVD. In patients with PAD the presence of isolated diastolic, systolic, or combined LVD was independently and equally associated with increased cardiovascular mortality, irrespective of the concomitant presence of DM. (Source: The American Journal of Cardiology)
Involvement of the Basilar Artery in Diabetes Mellitus: An MRI Study of Brainstem Infarctions
Eur Neurol 2010;64:230–235 (DOI:10.1159/000319924) (Source: Karger Publishers)
Peroxisome Proliferator-Activated Receptor-γ Agonist Rosiglitazone Prevents Albuminuria but Not Glomerulosclerosis in Experimental Diabetes
Am J Nephrol 2010;32:393–402 (DOI:10.1159/000320129) (Source: Karger Publishers)
Diabetes Drug Metformin Linked to Lower Lung Cancer Rate in Mice
Findings reflect those of population studies in humans, researchers say (Source: Pharmacy News - Doctors Lounge)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
Bariatric Surgery Cost-Effective in Very Obese With Diabetes
Both gastric bypass and gastric banding are cost-effective ways to reduce diabetes-associated
complications and mortality among severely obese individuals with diabetes, according to research published in the
September issue of Diabetes Care. (Source: Modern Medicine)
Human-IAPP disrupts the autophagy/lysosomal pathway in pancreatic ?-cells: protective role of p62-positive cytoplasmic inclusions
Human-IAPP disrupts the autophagy/lysosomal pathway in pancreatic β-cells: protective role of p62-positive cytoplasmic inclusions
Cell Death and Differentiation advance online publication, September 3, 2010. doi:10.1038/cdd.2010.111
Authors: J F Rivera, T Gurlo, M Daval, C J Huang, A V Matveyenko, P C Butler
& S Costes (Source: Cell Death and Differentiation)
FVB mouse genotype confers susceptibility to OVE26 diabetic albuminuria
OVE26 (OVE) diabetic mice on the inbred strain FVB are a valuable model of diabetic nephropathy that excretes the highest amount of urine albumin of all diabetic mouse models. Crossing of OVE mice to C57BL6 or DBA2 mice reduced albuminuria 17-fold in F1 diabetic offspring without reducing diabetes. When comparing renal histology of OVE mice on the FVB background to F1 C57BL6 crosses, we found that the F1 kidneys had significantly smaller glomeruli, much less albumin accumulation in tubules, reduced mesangial matrix expansion, and less interstitial fibrosis. A genome scan of 108 OVE-positive N2 offspring for albuminuria revealed one significant peak on chromosome 11 and nearly significant peaks on chromosomes 9, 13, and 19. Homozygosity for the FVB genotype for peaks on chromosomes 11, 13, ...
The pleiotropic actions of rosuvastatin confer renal benefits in the diabetic Apo-E knockout mouse
In conclusion, in the diabetic Apo-E–/– mouse, rosuvastatin confers renal benefits that are independent of lipid lowering and equivalent or greater to those observed with candesartan. The combination treatment is not superior to monotherapies. (Source: AJP: Renal Physiology)
Expression patterns of connective tissue growth factor and of TGF-{beta} isoforms during glomerular injury recapitulate glomerulogenesis
Transforming growth factor (TGF)-β1, -β2, and -β3 are involved in control of wound repair and development of fibrosis. Connective tissue growth factor (CTGF) expression is stimulated by all TGF-β isoforms and is abundant in glomerulosclerosis and other fibrotic disorders. CTGF is hypothesized to mediate profibrotic effects of TGF-β1 or to facilitate interaction of TGF-β1 with its receptor, but its interactions with TGF-β isoforms in nonpathological conditions are unexplored so far. Tissue repair and remodeling may recapitulate gene transcription at play in organogenesis. To further delineate the relationship between CTGF and TGF-β, we compared expression patterns of CTGF and TGF-β isoforms in rat and human glomerulogenesis and in various human g...<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
School Children Who Eat Vending Machine Foods Face Increased Risks for Chronic Health Problems, Poor Diet
September 2, 2010 (U-M) - School children who consume foods purchased in vending machines are more likely to develop poor diet quality ? and that may be associated with being overweight, obese or at risk for chronic health problems such as diabetes and coronary artery disease, according to research from the University of Michigan Medical School.
The study also looked at foods sold in school stores, snack bars and other related sales that compete with USDA lunch program offerings and found that these pose the same health and diet risks in school-aged children.
read more (Source: Diabetes News from dLife.com)
Acasti Pharma Inc. Reports Positive Impacts on Cardiometabolic Associated Disorders
LAVAL, Quebec, Sept. 2, 2010 (GLOBE NEWSWIRE) -- This release replaces and supersedes the press release sent earlier today. Acasti Pharma Inc., a subsidiary of Neptune Technologies & Bioressources Inc. ("Neptune") (Nasdaq:NEPT) (TSX-V:NTB) reports significant results on the effects of its anti-dyslipidemic investigational drug candidate CaPre(tm) on C-reactive protein (CRP) levels, a biomarker of CardioVascular Disease risk (CVD) and associated with diabetes and obesity. (Source: Medical News (via PRIMEZONE))
Sugar not a painkiller for babies
Conclusion
This study has used objective measures of pain in a small sample of infants and used careful blinding and randomisation to reduce bias. There are a few limitations due to the study size, but the conclusions are likely to challenge the currently held belief that sugar is an effective treatment for the pain of minor procedures in infants. The limitations mentioned by the researchers were:
The small sample size of 44 infants analysed, which could mean that this study was not powered to observe subtle effects that sucrose might have on the brain processes used for pain.
A measure of pain in infants is necessarily indirect (because they cannot describe the sensation), and so even though the electrophysiological measures reported in this study are more objective it is not clear ...
How Fish Oil Fights Inflammation
Omega-3 fatty acids work via a specific receptor and may combat diabetes as well (Source: ScienceNOW)
Moving Diabetes Genetics Beyond Genome-Wide Association Studies
Dr. Ali Torkamani summarizes key sessions from the American Diabetes Association's 70th Scientific Sessions and discusses how genetic investigations can assist in our understanding of type 1 and type 2 diabetes. Medscape Genomic Medicine (Source: Medscape Pathology Headlines)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
Lower Blood Pressure Goal Benefits African-Americans with Chronic Kidney Disease, Protein in the Urine
Source: National Institute of Diabetes and Digestive and Kidney Diseases -
Related MedlinePlus Pages: African-American Health, Kidney Diseases (Source: MedlinePlus Health News)
Long Term Data Presented at ESC 2010 Further Support the Benefit of The CYPHER(R) Sirolimus Drug-Eluting Stent Compared to The ENDEAVOR(R) Zotarolimus-Eluting Stent in Important High-Risk Subgroups
Additional Analysis of 18 Month Data of the SORT OUT III Trial Provides Detail on Safety and Efficacy Outcomes in Patients With Diabetes, Acute Coronary Syndrome, or Treatment of Multiple Lesions
STOCKHOLM, September 2, 2010 (HSMN NewsFeed) --Three ne... Devices, Interventional CardiologyCordis, CYPHER, Sirolimus, Drug Eluting Stent, Zotarolimus, Medtronic (Source: HSMN NewsFeed)
EMAS Publishes Position Statements About the Post-Reproductive Health of Women
September 2, 2010 (EurekAlert) - Elsevier announced today the publication of four important position statements from the European Menopause and Andropause Society (EMAS) in the journal Maturitas on common management problems in the post-reproductive health of women. The statements cover the management of the menopause in the context of obesity, epilepsy, endometriosis and premature ovarian failure. Each statement has summary recommendations as a quick aid for the busy clinician.
read more (Source: Diabetes News from dLife.com)
Diabetes 2 Drug Metformin May Protect Against Lung Cancer In Smokers
Two studies reveal that smokers may have a significantly lower risk of developing lung cancer and colorectal cancer with the drug metformin, which is commonly prescribed for diabetes type 2 treatment, the medical journal Cancer Prevention Research informs. Metformin, originally sold as Glucophage, is the first-line drug of choice for diabetes type 2 patients, especially those who are obese or overweight, as well as diabetes patients with normal kidney function. Metformin may have the following brand names: Fortamet, Glucophage, Glucophage XR, Glumetza, or Riomet... (Source: Health News from Medical News Today)
Halozyme Begins Phase 2 Clinical Trials With Insulin Analogs Lispro and Aspart With rHuPH20 In Type 1 And Type 2 Diabetes
Halozyme Therapeutics, Inc. (Nasdaq: HALO) today announced the initiation of two Phase 2 Ultrafast Insulin treatment studies that utilize its rHuPH20 hyaluronidase enzyme (PH20) in combination with the two leading commercially available mealtime analogs: insulin aspart, the active ingredient in NovoLog®, and insulin lispro, the active ingredient in Humalog®. (Source: Pharmaceutical Online News)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
Acasti Pharma Inc. Reports Positive Impacts on Obesity and Cardiometabolic Associated Disorders
LAVAL, Quebec, Sept. 2, 2010 (GLOBE NEWSWIRE) -- Acasti Pharma Inc., a subsidiary of Neptune Technologies & Bioressources Inc. ("Neptune") (Nasdaq:NEPT) (TSX-V:NTB) reports significant results on the effects of its anti-dyslipidemic investigational drug candidate CaPre(tm) on C-reactive protein (CRP) levels, a biomarker of CardioVascular Disease risk (CVD) and associated with diabetes and obesity. (Source: Medical News (via PRIMEZONE))
Agent Orange Cases Expanded; Added Costs Raise Fiscal Concerns
The Associated Press/Washington Post: Hundreds of thousands of Vietnam War veterans are receiving disability compensation for diseases normally associated with aging - not combat - because of the possibility of a link Agent Orange exposure. The diseases in question range from diabetes, for which 270,000 veterans receive Agent Orange-related checks, to erectile dysfunction. "And taxpayers may soon be responsible for even more: VA said Monday that it will add heart disease, Parkinson's disease and certain types of leukemia to the list of conditions that might be connected to Agent Orange... (Source: Health News from Medical News Today)
Familial prevalence of autoimmune disorders in multiple sclerosis in Northern Greece
Conclusions: There is a longitudinally increased frequency of additional autoimmune disorders among multiple sclerosis family members, probably related to immunomodulatory therapy. (Source: Multiple Sclerosis)
Coronary revascularisation in the patient with diabetes: balancing risk and benefit
(Source: Heart)
Association between admission hypoglycaemia and in-hospital and 3-year mortality in older patients with acute myocardial infarction
Conclusions
In older patients with AMI, increased as well as decreased admission FPG levels could predict higher in-hospital and 3-year mortality. There was a striking U-shaped relationship between admission FPG levels and short- and long-term mortality. An initial admission FPG level ≥ 5.1 to≤7.0 mmol/l may be desirable because it was associated with better clinical outcomes. (Source: Heart)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
Unilife Corporation Secures FDA 510k Clearance For The Unitract? 1mL Tuberculin Syringe
Unilife Corporation ("Unilife" or "Company") (Nasdaq: UNIS, ASX: UNS), announced that its Unitract? Tuberculin (TB) Syringe has received 510(k) market clearance from the U.S. Food and Drug Administration (FDA). The Unitract? TB syringe is a variant of the Unitract? 1mL Insulin Syringe for which Unilife secured FDA clearance earlier this year. Unlike insulin syringes which are primarily used by people with diabetes, TB syringes are used for the administration of a range of therapeutic drugs and vaccines within acute-care hospitals and other healthcare facilities... (Source: Health News from Medical News Today)
Telemedicine Helps Native Americans
Source: Carolyn Bloch, Federal Telemedicine News Content: “The University of California, Davis School of Medicine is using grant funding to train Native American communities in the state. The training sites include the Round Valley Indian Tribes of Covelo, Mendocino County, and communities served by Northern Valley Indian Health Inc. that includes Glenn County and portions [...] (Source: ICMCC: The International Council on Medical and Care Compunetics)
Original Article: Potential CYP2C9?mediated drug?drug interactions in hospitalized type 2 diabetes mellitus patients treated with the sulphonylureas glibenclamide, glimepiride or glipizide
Abstract.? (Source: Journal of Internal Medicine)
pSivida Announces Iluvien(R) Receives FDA Priority Review For Treatment Of Diabetic Macular Edema
pSivida Corp. (NASDAQ:PSDV) (ASX:PVA), a leader in the development of sustained release back of the eye drug delivery systems for difficult-to-treat conditions, announced that its licensee, Alimera Sciences (NASDAQ:ALIM) has been notified that the U.S. Food and Drug Administration (FDA) has granted Priority Review status for the New Drug Application (NDA) filed for Iluvien for the treatment diabetic macular edema (DME). FDA Priority Review status is given to therapies that offer major advances in treatment, or provide a treatment where no adequate therapy exists... (Source: Health News from Medical News Today)
New Study Singles Out Factors Linked To Cognitive Deficits In Type 2 Diabetes
Older adults with diabetes who have high blood pressure, walk slowly or lose their balance, or believe they're in bad health, are significantly more likely to have weaker memory and slower, more rigid cognitive processing than those without these problems, according to a new study published by the American Psychological Association. These three health factors stood out from more than a dozen suspected to shape how Type 2 diabetes is frequently shadowed by cognitive impairment, including dementia... (Source: Health News from Medical News Today)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
Growing Obesity, Diabetes Epidemics In California
A majority of adults in California are obese or overweight, and more than 2 million have been diagnosed with diabetes, according to a new study from the UCLA Center for Health Policy Research. Both conditions - which are related to each other as well as to heart disease - increased significantly in just six years, with the prevalence of diabetes alone jumping nearly 26 percent between 2001 and 2007. The "epidemic" of obesity and diabetes leaves no racial, ethnic, economic or geographic segment of the state unscathed, according to the researchers... (Source: Health News from Medical News Today)
Angola: Diabetes Association Set Up in Huíla
An Angolan Diabetes Association (ASDA) was set up on Tuesday, in Lubango City, in the southern Huíla Province, aimed at warning, training and educating sufferers of this disease on how to fight against diabetes. (Source: AllAfrica News: Health and Medicine)
ACE I-ARB combination therapy not detrimental to severely hypertensive diabetics
Australian researchers suggest that combined ACE inhibitor and angiotensin receptor blocker antihypertensive therapy does not produce more renal damage than monotherapy with either drug in diabetes patients with severe hypertension. (Source: MedWire News - Diabetes)
Increased risk of death in men with insomnia and a short sleep duration
Men with chronic insomnia who slept for less than six hours were four times more likely to die during the 14-year follow-up period, according to a new study. Results were adjusted for potential confounders such as body mass index, smoking status, depression and obstructive sleep apnea. Further adjustments for hypertension and diabetes had little effect on the elevated mortality risk. No significant mortality risk was found in women with insomnia and a short sleep duration of less than six hours. (Source: ScienceDaily Headlines)
Bigger role for pharmacists planned
Pharmacies in Scotland will provide a five-star chronic medication service for patients with conditions like diabetes and high blood pressure (Source: Pharmacy Europe)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
Potential remains for PPAR-targeted drugs
Nature Reviews Drug Discovery 9, 668 (2010). doi:10.1038/nrd3271
Author: Dan Jones
The controversy over the diabetes drug rosiglitazone (Avandia; GlaxoSmithKline), a peroxisome proliferator-activated receptor-? agonist, has undermined confidence in developing drugs that target this family of nuclear receptors, but some companies still see promise in the field. (Source: Nature Reviews Drug Discovery)
Deal watch: Metabolex and Sanofi?Aventis partner on GPCR agonists for type 2 diabetes
Nature Reviews Drug Discovery 9, 670 (2010). doi:10.1038/nrd3255
Metabolex has entered into an agreement with Sanofi?Aventis for the development of small molecules that target G protein-coupled receptor 119 (GPR119), the most advanced of which is in a Phase II trial for the treatment of type 2 diabetes (T2D). Metabolex will receive upfront and (Source: Nature Reviews Drug Discovery)
Children who eat vended snack foods face chronic health problems, poor diet
(University of Michigan Health System) School children who consume foods purchased in vending machines are more likely to develop poor diet quality -- and that may be associated with being overweight, obese or at risk for chronic health problems such as diabetes and coronary artery disease, according to research from the University of Michigan Medical School. (Source: EurekAlert! - Biology)
Variation in Quality of Care Indicators for Diabetes in a National Sample of Veterans and Non-Veterans
Diabetes Technology & Therapeutics , Vol. 0, No. 0. (Source: Diabetes Technology)
Most diabetics need better BP control to reach targets
Belgian researchers report that only 16% of patients with Type 2 diabetes achieve the target blood pressure of 130/80 mmHg recommended by American and European regulatory bodies such as the European Society of Hypertension. (Source: MedWire News - Diabetes)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
Diabetes drug can reduce risk of cancer, researchers find
Metformin reduced the development of lung tumors in mice by more than 70%. Clinical trials on humans for lung, breast and prostate cancer are being organized.A growing body of evidence suggests that the widely used diabetes drug metformin can reduce the risk of cancer, researchers said Wednesday. (Source: Los Angeles Times - Science)
Diabetes drug can reduce risk of cancer, researchers find
Metformin reduced the development of lung tumors in mice by more than 70%. Clinical trials on humans for lung, breast and prostate cancer are being organized.A growing body of evidence suggests that the widely used diabetes drug metformin can reduce the risk of cancer, researchers said Wednesday. (Source: L.A. Times - Health)
Sphingolipids as Signaling and Regulatory Molecules
series:Advances in Experimental Medicine and BiologyThis book attempts to analyze the latest discoveries in sphingolipid biology and how the alteration of their metabolism leads to altered signaling events and to the development of pathobiological disorders, such as cancer, cardiovascular diseases, asthma, diabetes, inflammation and infectious diseases. (Source: Springer Biomedical Sciences titles)
Prevalence of erectile dysfunction among Chinese men with type 2 diabetes mellitus
Authors: G Yang, C Pan
& J Lu (Source: International Journal of Impotence Research)
Epidemiological and economic burden of metabolic syndrome and its consequences in patients with hypertension in Germany, Spain and Italy; a prevalence-based model.
Conclusion:
The presence of metabolic syndrome in patients with hypertension significantly inflates economic burden and costs are likely to increase in the future due to an aging population and an increase in the prevalence of components of metabolic syndrome. (Source: BMC Public Health - Latest articles)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
Increased levels of CRP and MCP-1 are associated with previously unknown abnormal glucose regulation in patients with acute STEMI: a cohort study.
Conclusion:
Elevated levels of CRP and MCP-1 measured in patients early after an acute STEMI were associated with abnormal glucose regulation classified by an OGTT at three-month follow-up. No significant associations were observed between inflammatory markers and hyperglycaemia measured during the acute STEMI. (Source: Cardiovascular Diabetology)
FDA updates drug label for tigecycline (Tygacil®) to warn of increased mortality risk
Source: FDA
Area: News
The FDA has issued a reminder to healthcare professionals of an increased mortality risk associated with the use of the intravenous antibiotic tigecycline (Tygacil®) compared to that of other drugs used to treat a variety of serious infections. The increased risk was more pronounced in patients treated for hospital-acquired pneumonia, especially ventilator-associated pneumonia, but was also seen in patients with complicated skin and skin structure infections, complicated intra-abdominal infections and diabetic foot infections. The Agency has updated sections of the drug label to include information about this increased mortality risk and suggested that alternatives should be considered in patients with severe infections. (Source: NeLM - News)
Survey on access to insulin pump therapy
Source: Medical Technology Group (MTG),
Area: News
The Medical Technology Group (MTG), a coalition of patient groups, research charities and medical device manufacturers, has published the findings of its survey of 152 PCTs about access to insulin pump therapy, which confirmed that overall uptake and utilisation for insulin pump therapy remains extremely low.
The survey found that:
. The average rate of insulin pump provision for people with type 1 diabetes is 3.9% compared to the 12% benchmark recommended by NICE.
. Two PCTs gave information which suggests they are providing insulin pumps in line with the NICE benchmark.
. Five out of 113 PCTs have a strategy in place to implement NICE guidance on insulin pumps in line with their...
Intensive BP control in black patients with CKD may reduce disease progression in some
Source: New England Journal of Medicine
Area: News
Further analysis of long-term follow up of patients from the AASK study found indications that intensive blood pressure (BP) control might reduce chronic kidney disease (CKD) progression in those with baseline proteinuria.
AASK tested antihypertensive regimens based on three drug groups in non-diabetic African-American patients with hypertension and signs of renal impairment, to determine whether any drug class was superior and whether more intensive BP control had advantages. Drugs used were ramipril, amlodipine, and metoprolol: the amlodipine arm was stopped early due to poorer outcomes. The results from the original trial, published in 2002 (JAMA 2002; 288(19): 2421-31), did not show any superiority for intensive BP control ...
Readily available clinical descriptions can help assess cardiovascular event risk in atherosclerotic patients
Source: JAMA
Area: News
Evaluation of outcomes in a large multi-national registry of people with atherosclerosis suggests that a number of simple descriptors can identify those at greatest risk of cardiovascular events.
It is often difficult to identify which patients are at the highest risk for cardiovascular events, although being able to do this would be of great value to both practising clinicians and to those carrying out clinical trials. Prior ischaemic events, polyvascular disease, and diabetes have all been identified as predictors of ischaemic events, but their comparative contributions to future risk remain unclear. The authors of this paper used data from the Reduction of Atherothrombosis for Continued Health (REACH) Registry to examine the contribution to overall ri...<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
Review: Balancing risk and benefit of coronary revascularisation in patients with diabetes
Source: Heart
Area: News
This review addresses two important clinical questions about revascularisation in patients with diabetes:
1. In medically-treated non-ACS patients, should revascularisation (CABG or PCI) be offered initially or should it be delayed?
2. When does CABG offer benefits over PCI?
The following topics are discussed:
. Revascularisation versus medical therapy in diabetes
. Bypass Angioplasty Revascularisation Investigation 2 Diabetes trial (BARI 2D) main findings
. Limitations of BARI 2D
. CABG versus PCI in diabetes
. Ongoing study of CABG versus PCI in diabetes
. Clinical implications for patients with diabetes
. Patient involvement
. Advances in medical and surgical ther...
Review: Saxagliptin for type 2 diabetes mellitus
Source: American Journal of Health-System Pharmacy
Area: News
This review: on saxagliptin, a dipeptidyl peptidase-4 inhibitor for the treatment of type 2 diabetes mellitus examines its pharmacology, pharmacokinetics, efficacy, safety, and dosage and administration. (Source: NeLM - News)
Annual Evidence Updates planned for September 2010
Source: NHS Evidence
Area: News
NHS Evidence has announced the following Annual Evidence Updates planned for September 2010:
6 September
Epilepsy
Gastrointestinal symptoms in supportive and palliative care
13 September
Alzheimer's disease and dementia
Diabetic Retinopathy
Eczema
20 September
Osteoarthritis
Surgical aspects of faecal incontinence
27 September
Amblyopia
Antenatal and pregnancy care (Source: NeLM - News)
Pneumomediastinum as a complication of emphysematous cholecystitis: case report
Conclusion:
Emphysematous cholecystitis should be considered as a possible cause of pneumomediastinum. (Source: BMC Gastroenterology)
Proposed Diabetes Test Misses Most Cases: Study
A new proposed diabetes test could miss millions of cases of diabetes and pre-diabetes and also over-diagnose black Americans, suggests a new study published online July 16th in Diabetes Care. Reuters Health Information (Source: Medscape Pathology Headlines)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
Previous gestational diabetes impairs long-term endothelial function in a mouse model of complicated pregnancy
Women who develop gestational diabetes mellitis (GDM) display endothelial dysfunction up to 1 yr after pregnancy, despite a return to normoglycemia. It is unknown whether this dysfunction was preexisting or whether GDM pregnancy leads to long-term endothelial dysfunction. A mouse model that spontaneously develops GDM (Leprdb/+) was used to determine whether the endothelial dysfunction that develops during GDM is evident in later life. Heterozygous and wild-type (WT) controls were allowed to litter once, then age to 9–10 mo, and were compared with virgin controls. Vascular function of small mesenteric arteries was assessed using wire myography. Concentration response curves to the thromboxane A2mimetic U46619 and the endothelium-dependent vasodilator methacholine were constructed. Sup...
Metabolic profiling of muscle contraction in lean compared with obese rodents
Interest in the pathophysiological relevance of intramuscular triacylglycerol (IMTG) accumulation has grown from numerous studies reporting that abnormally high glycerolipid levels in tissues of obese and diabetic subjects correlate negatively with glucose tolerance. Here, we used a hindlimb perfusion model to examine the impact of obesity and elevated IMTG levels on contraction-induced changes in skeletal muscle fuel metabolism. Comprehensive lipid profiling was performed on gastrocnemius muscles harvested from lean and obese Zucker rats immediately and 25 min after 15 min of one-legged electrically stimulated contraction compared with the contralateral control (rested) limbs. Predictably, IMTG content was grossly elevated in control muscles from obese rats compared with their lean counte...
Maternal obesity and fetal metabolic programming: a fertile epigenetic soil
The incidence of obesity and overweight has reached epidemic levels in the United States and developed countries worldwide. Even more alarming is the increasing prevalence of metabolic diseases in younger children and adolescents. Infants born to obese, overweight, and diabetic mothers (even when normal weight) have increased adiposity and are at increased risk of later metabolic disease. In addition to maternal glucose, hyperlipidemia and inflammation may contribute to the childhood obesity epidemic through fetal metabolic programming, the mechanisms of which are not well understood. Pregravid obesity, when combined with normal changes in maternal metabolism, may magnify increases in inflammation and blood lipids, which can have profound effects on the developing embryo and the fetus in u...
Diabetes drug may keep lung cancer at bay
CHICAGO (Reuters) - The common diabetes drug metformin may hold promise as a way to keep smokers from developing lung cancer, U.S. researchers said on Wednesday. (Source: Reuters: Health)
New Evidence That Fat Cells Are Not Just Dormant Storage Depots for Calories
September 1, 2010 (EurekAlert) - Scientists are reporting new evidence that the fat tissue in those spare tires and lower belly pooches ? far from being a dormant storage depot for surplus calories ? is an active organ that sends chemical signals to other parts of the body, perhaps increasing the risk of heart attacks, cancer, and other diseases.
read more (Source: Diabetes News from dLife.com)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
New Study Singles out Factors Linked to Cognitive Deficits in Type 2 Diabetes
September 1, 2010 (EurekAlert) - Older adults with diabetes who have high blood pressure, walk slowly or lose their balance, or believe they're in bad health, are significantly more likely to have weaker memory and slower, more rigid cognitive processing than those without these problems, according to a new study published by the American Psychological Association.
read more (Source: Diabetes News from dLife.com)
Immune System Research Sees Many Similarities Among People
Findings may lead to better diagnosis, treatment of cancers, autoimmune diseases, study says (Source: The Doctors Lounge - Neurology)
Diabetes drug shows potential as a cancer fighter
An inexpensive drug that's already used to treat type 2 diabetes could find new life as a cancer fighter, with two new studies suggesting it fights off colon cancer and even prevents lung cancer in smokers. (Source: CTV Health)
Diabetes Drug Metformin Linked to Lower Lung Cancer Rate in Mice
Findings reflect those of population studies in humans, researchers say
Source: HealthDay
Related MedlinePlus Pages: Diabetes Medicines, Lung Cancer (Source: MedlinePlus Health News)
Charcot neuroarthropathy: An often overlooked complication of diabetes
In patients with long-standing, poorly controlled diabetes and peripheral neuropathy, a red, hot, swollen foot without open ulceration should raise the suspicion of Charcot neuroarthropathy, an often-overlooked diabetic foot complication. The authors discuss key diagnostic features and how to differentiate this condition from cellulitis, osteomyelitis, and other conditions. They review key elements of the workup and emphasize the importance of early diagnosis and prompt treatment to preserve a functioning foot. (Source: Cleveland Clinic Journal of Medicine)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
Hospitalized Patients With 2009 H1N1 Influenza Infection: The Mayo Clinic Experience
CONCLUSION: Hospitalized adults with H1N1 influenza infection are relatively young, and a significant number require treatment in the ICU. Among the patients who require ICU admission, most develop acute lung injury or acute respiratory distress syndrome and require mechanical ventilator support. (Source: Mayo Clinic Proceedings)
Impact of Prevalent Fractures on Quality of Life: Baseline Results From the Global Longitudinal Study of Osteoporosis in Women
CONCLUSION: Previous fractures at a variety of bone locations, particularly spine, hip, and upper leg, or involving more than 1 location are associated with significant reductions in quality of life. (Source: Mayo Clinic Proceedings)
Balanced diet cuts heart risk
Conclusion
This well-conducted trial benefits from its relatively large size, accurate provision of the three randomised diets and high study completion rates (95%). It also featured a reliable study outcome by using the average of a series of blood pressure measures, which is preferable to relying on a single blood pressure reading.
The study found that eight weeks of the DASH diet, which was rich in fruit and vegetables and low in saturated fat, lowered blood pressure and cholesterol. This contributed to a decrease in predicted 10-year CHD risk. The DASH diet reduced this risk by 18% compared to a high-saturated fat ?American? diet and by 11% compared to a diet similar to the American diet but with higher intake of fruit and vegetables.
Some points to note when interpreting this stud...
Diabetes drug can reduce risk of cancer, researchers find
A growing body of evidence suggests that the widely used diabetes drug metformin can reduce the risk of cancer, researchers said Wednesday.
A study in mice exposed to tobacco carcinogens shows that the drug can reduce the development of lung tumors by... (Source: OrlandoSentinel: Medical Research)
Death risk from insomnia unclear
Conclusion
This study has found that in middle-aged men, self-reported insomnia and objectively measured short sleep duration was associated with a greater risk of death during the 14-year follow-up period, compared with men who did not have insomnia or short sleep duration. However, these findings require careful interpretation and do not prove that insomnia increases the risk of early death:
The study has an important limitation in that it is a secondary analysis of a study set up to assess the age distribution of people with sleep-disordered breathing. As such, the participants were not selected at random. All of them had a higher risk of sleep-disordered breathing, and the women had markedly higher BMIs. These factors may affect both mortality risk and insomnia. Therefore, the resul...<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
Less is More: Study Shows That Teens Who Sleep Less Eat More Fatty Foods and Snacks
September 1, 2010 (EurekAlert) - A study in the Sept. 1 issue of the journal Sleep shows that teens who slept less than eight hours per weeknight ate higher proportions of fatty foods and snacks than adolescents who slept eight hours or more. The results suggest that short sleep duration may increase obesity risk by causing small changes in eating patterns that cumulatively alter energy balance, especially in girls.
read more (Source: Diabetes News from dLife.com)
GI Dynamics Announces Distribution Agreement with Elemental Healthcare for the EndoBarrier Gastrointestinal Liner
LEXINGTON, Mass. & HUNGERFORD, England--(Healthcare Sales & Marketing Network)--GI Dynamics, a leader in non-surgical, endoscopic treatments for type 2 diabetes and obesity, today announced it has entered into a new agreement with Elemental Healthcare, bas... Devices, DistributionGI Dynamics, Elemental Healthcare, EndoBarrier (Source: HSMN NewsFeed)
Association of Interleukin-10 Polymorphisms with Cytokines in Type 2 Diabetic Nephropathy
Diabetes Technology & Therapeutics , Vol. 0, No. 0. (Source: Diabetes Technology)
The Fallacy of Hindsight: Response to Moses and Koenen
Diabetes Technology & Therapeutics , Vol. 0, No. 0. (Source: Diabetes Technology)
Lower Rate of Initial Failures and Reduced Occurrence of Adverse Events with a New Catheter Model for Continuous Subcutaneous Insulin Infusion: Prospective, Two-Period, Observational, Multicenter Study
Diabetes Technology & Therapeutics , Vol. 0, No. 0. (Source: Diabetes Technology)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
Analysis of Hemodialysis-Associated Hypoglycemia in Patients with Type 2 Diabetes Using a Continuous Glucose Monitoring System
Diabetes Technology & Therapeutics , Vol. 0, No. 0. (Source: Diabetes Technology)
Detrended Fluctuation Analysis Is Considered to Be Useful as a New Indicator for Short-Term Glucose Complexity
Diabetes Technology & Therapeutics , Vol. 0, No. 0. (Source: Diabetes Technology)
Inter-Day Glycemic Variability Assessed by Continuous Glucose Monitoring in Insulin-Treated Type 2 Diabetes Patients on Hemodialysis
Diabetes Technology & Therapeutics , Vol. 0, No. 0. (Source: Diabetes Technology)
MIF knockdown impairs glucose homeostasis
Macrophage migration inhibitory factor (MIF) is a cytokine which affects carbohydrate metabolism and has been linked to obesity and insulin resistance. Serre-Beinier and colleagues have shown that MIF plays an active role in insulin secretion and glucose homeostasis for the first time, using MIF knockout mice. MIF deficiency affected body weight gain; mice had a lower body weight at birth, whilst after birth a higher body weight gain was observed compared to wild type mice, due to increased food intake. Older mice without the MIF gene had impaired glucose tolerance, with an age-dependent increase in fasting insulin levels being observed. This leads to an increase in glucose uptake which may explain the increased fat mass of older mice.
Whilst further work needs to be done to elucidate MIF&...
Diabetes-Related Risk Factors and Cognitive Aging
Focus on Obesity, Insulin Resistance, and the Metabolic Syndrome (Source: Psychiatric Times)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
Whisky from the Urine of Diabetics
I learned of whisky made from the urine of diabetics while reading Slashdot today. Sugar is recovered from the urine of a diabetic person and is added to the whisky ...Read Full Post (Source: About.com Chemistry)
Improving Ocular Disease Screening By LED Illumination Of The Eye
A new imaging system using six different wavelengths to illuminate the interior of the eyeball (ocular fundus) may pave the way for doctors to easily screen patients for common diseases of the eye, such as age-related macular degeneration and diabetic retinopathy. The system is described in the journal Review of Scientific Instruments, which is published by the American Institute of Physics... (Source: Health News from Medical News Today)
Differences in cortical and pituitary activity in response to hypoglycaemia and cognitive testing in healthy men with different basal activity of the renin-angiotensin system
Conclusion. Basal RAS activity influenced cerebral activity. Low RAS was associated with more pronounced cortical activation in all glycaemic conditions. High RAS was associated with pituitary activation during hypoglycaemia and post-hypoglycaemia, and this was associated with a greater growth hormone response. (Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS)
Spironolactone ameliorates podocytic adhesive capacity via restoring integrin {alpha}3 expression in streptozotocin-induced diabetic rats
Podocyte responses to various injuries include detachment from the glomerular basement membrane (GBM) with impaired adhesion ability. Growing evidence suggests inappropriately enhanced aldosterone levels in glomeruli may contribute to podocytic injury and subsequently glomerulosclerosis in diabetic nephropathy (DN). In the present study, we aimed to investigate podocytic integrin 3 expression and urinary podocyte excretion in streptozotocin (STZ)-induced diabetic rats, and to evaluate their responses to spironolactone (SPL). STZ-induced male diabetic Wistar rats were treated with vehicle (the STZ group, n=7), or spironolactone (the STZ+SPL group, n=6) for 12 weeks, six additional rats of similar body weight serving as control. Urine specimens were obtained for measurement of urine albumin ...
ORIGINAL ARTICLE: Differences in mouse models of diabetes mellitus in studies of male reproduction
Summary (Source: International Journal of Andrology)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
Insomnia with Short Sleep Duration and Mortality: The Penn State Cohort
Conclusions: Insomnia with objective short sleep duration in men is associated with increased mortality, a risk that has been underestimated.
Keywords: Insomnia, short sleep duration, mortality, population-based study (Source: Sleep)
Comparison of family partnership intervention care vs. conventional care in adult patients with poorly controlled type 2 diabetes in a community hospital: A randomized controlled trial
This study aimed to compare FPIC with conventional care (CC) across a number of outcome measures in patients with poorly controlled type 2 diabetes.Design: The study was performed using a randomized controlled trial design.Participants: Patients with poorly controlled type 2 diabetes who were solely treated with oral antidiabetic agents and had at least two out of three hemoglobin A1C readings equal to or above 7% in the previous 12 months, were randomly assigned to the FPIC group (n=28) and to the CC group (n=28).Methods: Baseline and 6-month follow-up scores were compared using the following outcome measures: (1) hemoglobin A1C, (2) BMI, (3) lipid profile, (4) family supportive behaviours, (5), knowledge of and attitudes toward diabetes, and (6) diabetes self-care behaviours. Descriptive...
Crisps: a very British habit
They're fried in fat and smothered in salt, but still we eat a heart-stopping 6bn packets of them a year. So why do we have an unhealthy obsession with potato crisps?? Food blog: what's your favourite crisp?In an unremarkable suburb of Leicester called Beaumont Leys is a big factory ? or actually two, side by side. But let's not split hairs already. The point is that it's big; a winding 10-minute march from reception round to the delivery bays.These bays are where the raw material comes in, which is potatoes. The variety changes with the season, depending on whether they've come straight from the fields in summer, or from storage during winter. There are Hermes, Saturna and, right now, round, pink-cheeked Lady Rosetta.Let's follow her, briefly. She is washed out of the truck ? sheddi...
Retinal Detachment
Title: Retinal DetachmentCategory: Diseases and ConditionsCreated: 3/8/2000Last Editorial Review: 9/1/2010 (Source: MedicineNet Diabetes General)
Eicosapentaenoic acid as an add-on to antidepressant medication for co-morbid major depression in patients with diabetes mellitus: A randomized, double-blind placebo-controlled study
Abstract: Background: Depression is common in individuals with diabetes. The present study is the first randomized controlled trial to test the efficacy of ?-3 ethyl-eicosapentaenoic acid (E-EPA) as adjuvant to antidepressant medication in the treatment of depression in adults with diabetes mellitus.Methods: In the VU University Medical Center, we conducted a 12-week, placebo-controlled, double-blind, parallel-group intervention study of E-EPA (1g/day) versus placebo in 25 diabetes patients meeting DSM-IV criteria for major depressive disorder, who were already using antidepressant medication. The primary outcome was severity of depressive symptoms, assessed by the Montgomery Åsberg Depression Rating Scale (MADRS) at baseline and 12-week follow-up at two-weekly intervals. Blood samples w...<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
Behind the headlines - Genetic effects of vitamin D studied
?Stocking up on vitamin D supplements and enjoying the summer sun could cut the risk of a host of diseases,? reported the Daily Mail. This news story is based on a study that investigated how vitamin D might influence the risk of certain diseases by affecting the activity of genes. It found that vitamin D binds directly to genes associated with several common autoimmune diseases, including multiple sclerosis, type 1 diabetes, rheumatoid arthritis and colorectal cancer. Studies of this kind add to our knowledge of the function of vitamin D, and will be used to assess the guidelines for recommended vitamin D intake. What does NHS Choices make of this study? This is a valuable addition to our knowledge of the effects of vitamin D in the cells and how it might affect our risk of certain di...
Behind the headlines - Genetic effects of vitamin D studied
?Stocking up on vitamin D supplements and enjoying the summer sun could cut the risk of a host of diseases,? reported the Daily Mail. This news story is based on a study that investigated how vitamin D might influence the risk of certain diseases by affecting the activity of genes. It found that vitamin D binds directly to genes associated with several common autoimmune diseases, including multiple sclerosis, type 1 diabetes, rheumatoid arthritis and colorectal cancer. Studies of this kind add to our knowledge of the function of vitamin D, and will be used to assess the guidelines for recommended vitamin D intake. What does NHS Choices make of this study? This is a valuable addition to our knowledge of the effects of vitamin D in the cells and how it might affect our risk of certain di...
Diabetes may speed up progression of mild cognitive impairment
The presence of diabetes in patients with mild cognitive impairment can accelerate progression to dementia by more than 3 years, a Swedish study suggests. (Source: MedWire News - Diabetes)
Behind the headlines - Genetic effects of vitamin D studied
?Stocking up on vitamin D supplements and enjoying the summer sun could cut the risk of a host of diseases,? reported the Daily Mail. This news story is based on a study that investigated how vitamin D might influence the risk of certain diseases by affecting the activity of genes. It found that vitamin D binds directly to genes associated with several common autoimmune diseases, including multiple sclerosis, type 1 diabetes, rheumatoid arthritis and colorectal cancer. Studies of this kind add to our knowledge of the function of vitamin D, and will be used to assess the guidelines for recommended vitamin D intake. What does NHS Choices make of this study? This is a valuable addition to our knowledge of the effects of vitamin D in the cells and how it might affect our risk of certain di...
Study finds an increased risk of death in men with insomnia and a short sleep duration
(American Academy of Sleep Medicine) Men with chronic insomnia who slept for less than six hours were four times more likely to die during the 14-year follow-up period. Results were adjusted for potential confounders such as body mass index, smoking status, depression and obstructive sleep apnea. Further adjustments for hypertension and diabetes had little effect on the elevated mortality risk. No significant mortality risk was found in women with insomnia and a short sleep duration of less than six hours. (Source: EurekAlert! - Medicine and Health)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
New study singles out factors linked to cognitive deficits in type 2 diabetes
(American Psychological Association) Older adults with diabetes who have high blood pressure, walk slowly or lose their balance, or believe they're in bad health, are significantly more likely to have weaker memory and slower, more rigid cognitive processing than those without these problems, according to a new study published by the American Psychological Association. (Source: EurekAlert! - Medicine and Health)
JCI online early table of contents: Sept. 1, 2010
(Journal of Clinical Investigation) This release contains summaries, links to PDFs, and contact information for the following newsworthy papers to be published online, Sept. 1, 2010, in the JCI: "Protecting nerve cells from death in a model of stroke"; "Modified adenovirus malaria vaccine works a treat in mice"; "Mechanisms of testicular cancer drug resistance"; "Pacifying protein levels to treat diabetes"; "Preemptive approach to decreasing scarring in the heart"; and others. (Source: EurekAlert! - Cancer)
Continuous Glucose Monitoring Reveals Delayed Nocturnal Hypoglycemia After Intermittent High-Intensity Exercise in Nontrained Patients with Type 1 Diabetes
Diabetes Technology & Therapeutics , Vol. 0, No. 0. (Source: Diabetes Technology)
Effective Intervention or Child's Play? A Review of Video Games for Diabetes Education
Diabetes Technology & Therapeutics , Vol. 0, No. 0. (Source: Diabetes Technology)
Use of Insulin Pumps in India: Suggested Guidelines Based on Experience and Cultural Differences
Diabetes Technology & Therapeutics , Vol. 0, No. 0. (Source: Diabetes Technology)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
University opens £600k unit to help fight against diabetes
A NEW £600,000 research facility at Perth Royal Infirmary, funded by the Dundee University's Diabetes Research Campaign, was officially opened yesterday by broadcaster Fre (Source: Scotsman.com News - Health)
Breastfeeding may lower diabetes risk in mothers
Mothers who breastfeed their children for at least 1 month may have a lower risk for diabetes than those who breastfeed for less time or do not breast feed at all, US researchers report. (Source: MedWire News - Diabetes)
Adding Alogliptin to Pioglitazone Is Effective First-Line Option for Type 2 Diabetes
The combination of the dipeptidyl peptidase (DPP)-4 inhibitor alogliptin and the thiazolidinedione pioglitazone reduces HbA1c when type 2 diabetes isn't controlled by diet and exercise, a randomized study has shown. Reuters Health Information (Source: Medscape Diabetes Headlines)
Beyond statin therapy: a review of the management of residual risk in diabetes mellitus
This article will review dyslipidaemia and its role in DM, and will discuss available treatment modalities that address residual cardiovascular risk in this disease. (Source: JRSM)
Predictors of direct costs of diabetes care in pediatric patients with type 1 diabetes
(Source: Pediatric Diabetes)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
Improving diabetes care in a public hospital medical clinic: report of a completed audit cycle
(Source: Journal of Evaluation in Clinical Practice)
AAFP-CIHI10 Global Burden of Chronic Disease (Edward Shahady MD)
Chronic diseases including cardiovascular disease, diabetes, and cancer, are the leading cause of death and disability in both the developed and developing world (excluding sub-Saharan Africa). Developing countries face the triple menace of trauma, infectious/communicable diseases and the increasing burden of non-communicable/chronic diseases like diabetes and cardiovascular disease and cancer. Urbanization, lifestyle changes and aging of populations contribute to the epidemic of chronic disease. Prolonged exposure to risk factors increases the probability of chronic disease development. Strategies that are within the resources of a country are needed to address this epidemic. This session will discuss the prevalence of global chronic disease and strategies like the poly pill care and othe...
Pregnancy: A Screening Test for Later Life Cardiovascular Disease
Cardiovascular disease is the major cause of death in women. Heart disease presents special problems to women, as first events are more likely to be fatal. These observations have led to attempts to increase recognition of risk for the disease by care providers and women and to identify women at risk. In 2007, the American Heart Association updated their Evidence Based Guidelines for Cardiovascular Disease Prevention in Women (). In it, they presented guidelines for evaluating risk for cardiovascular disease in women. Interestingly, in the text, tables, and flow charts there is no mention of obtaining a pregnancy history. In the text there is mention: ?preeclampsia may be an early indicator of CVD risk.? In this presentation, we point out there is no doubt that preeclampsia is associat...
Self-Reported Delays in Receipt of Health Care among Women with Diabetes and Cardiovascular Conditions
Conclusion: Women are more likely to experience delays in health care, even after adjusting for health coverage. Efforts are needed to understand factors that influence gender differences in these delays and to determine whether policy reforms eliminate or exacerbate these differences. (Source: Womens Health Issues)
Racial/Ethnic Disparities in Gestational Diabetes Mellitus: Findings from a Population-Based Survey
Conclusion: Non-Hispanic API women, especially Asian women with both normal and high BMI, have increased risk of GDM. Future research should examine the unique risk factors experienced by Asians and health practitioners should be vigilant in screening for GDM regardless of BMI. (Source: Womens Health Issues)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
Impact of early psychosocial factors (childhood socioeconomic factors and adversities) on future risk of type 2 diabetes, metabolic disturbances and obesity: a systematic review
Conclusions:
Taken together, there is evidence that childhood SES is associated with type 2 diabetes and obesity in later life. The database on the role of psychological factors such as traumata and childhood adversities for the future risk of type 2 diabetes or obesity is too small to draw conclusions. Thus, more population-based longitudinal studies and international standards to assess psychosocial factors are needed to clarify the mechanisms leading to the observed health disparities. (Source: BMC Public Health - Latest articles)
Serum transforming growth factor ?1 during diabetes development in non?obese diabetic mice and humans
(Source: Clinical and Experimental Immunology)
Original Paper: Telmisartan Effects on Insulin Resistance in Obese or Overweight Adults Without Diabetes or Hypertension
J Clin Hypertens (Greenwich). 2010;12:746?752. © (Source: The Journal of Clinical Hypertension)
Is antidepressive use associated with increased risk of diabetes?
Source: Diabetes Care
Area: News
Follow-up of participants in a diabetes prevention study found an association between continuous use of antidepressive drugs and increased risk of overt diabetes in a high-risk population.
The Diabetes Prevention Program (DPP) examined whether lifestyle change or metformin treatment affected the risk of developing diabetes in a high-risk population: the study was stopped when it showed that both active interventions were more effective than placebo and consenting participants were followed-up in the Diabetes Prevention Program Outcomes Study (DPPOS). An earlier report from the Program noted an association between antidepressive drug use and development of diabetes, and this paper reports an assessment of the association after ten years follow-up...
FDA grants priority review of fluocinolone acetonide (IluvienT) for diabetic macular oedema
Source: BioSpace
Area: News
Biospace has reported that the U.S. Food and Drug Administration (FDA) has granted fluocinolone acetonide intravitreal insert (IlluvienT) Priority Review status for the treatment of diabetic macular oedema.
Iluvien is a sustained drug delivery system that releases sub-microgram levels of fluocinolone acetonide and is currently being investigated in two global Phase 3 pivotal clinical trials (collectively known as the FAME Study) involving 956 patients (Source: NeLM - News)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
Contents
(Source: Journal of Diabetes and Its Complications)
Fatty Liver Linked to Insulin Resistance in Obese Teens
In obese adolescents, fatty liver -- independent of visceral fat and intramyocellular lipid content --
is associated with impaired insulin activity in the muscles and liver; along with other findings, this suggests the
liver plays a key role in insulin resistance in these individuals, according to research published in the August
issue of Diabetes Care. (Source: Modern Medicine)
Growth Factor Inhibition May Help Diabetes Patients
Inhibiting transforming growth factor-β1 expression in CD34+ cells may prove therapeutic
for patients with type 2 diabetes by increasing the cells' vascular repair ability, according to research published
in the August issue of Diabetes. (Source: Modern Medicine)
Sibutramine May Raise Risks in Those With CVD, Diabetes
In overweight or obese subjects with cardiovascular disease and diabetes, long-term use of sibutramine
is associated with an increased risk of nonfatal myocardial infarction and nonfatal stroke but not cardiovascular
death or any-cause death, according to a study in the Sept. 2 issue of the New England Journal of
Medicine. (Source: Modern Medicine)
The Development of a Pressure Ulcer Risk-Assessment Scale for Perioperative Patients
Abstract: The high incidence of pressure ulcer development in patients in the perioperative setting indicates the need for improved risk assessment and the use of preventive measures. A clinical nurse specialist used Dever's Epidemiological Model as the theoretical framework to develop a perioperative pressure ulcer risk-assessment scale. The risk factors for the scale were based on findings from a review of the literature. The scale, along with a demographic questionnaire and an evaluation form, was distributed to 12 nurses and three anesthesiologists to obtain expert opinion to further the design of the scale. Twelve participants returned the forms. Only four of the participants had previous experience with a pressure ulcer risk-assessment scale. The results indicated that diabetes shoul...<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
Diet and weight gain characteristics of pregnant women with gestational diabetes
Authors: M Salmenhaara, L Uusitalo, U Uusitalo, C Kronberg-Kippilä, H Sinkko, S Ahonen, R Veijola, M Knip, M Kaila
& S M Virtanen (Source: European Journal of Clinical Nutrition)
Microplasmin for Vitreomacular Traction
We congratulate de Smet et al. on their article about microplasmin in patients with vitreomacular traction before vitrectomy. In previous publications we have reported our results with autologous plasmin enzyme (APE) in diabetic macular edema, macular epiretinal membranes (MEM), and vitreomacular traction syndromes (VMTS). We continue our research in patients with various causes of macular edema where the vitreous is attached to the retina, and this seems to be the cause of the persistence of the edema or its worsening. (Source: Ophthalmology)
Traffic Trouble: Study Links Diabetes to Vehicular Pollution
(Source: EHP-in-Press)
The association between the spatial QRS?T angle with cardiac autonomic neuropathy in subjects with Type?2 diabetes mellitus
(Source: Diabetic Medicine)
Predictors of incident major depression in diabetic outpatients with subthreshold depression
(Source: Diabetic Medicine)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
The effect of diabetes mellitus on age?associated lean mass loss in 3153 older adults
(Source: Diabetic Medicine)
An exploration of knowledge and attitudes related to pre?pregnancy care in women with diabetes
(Source: Diabetic Medicine)
N?terminal fragment of pro?brain natriuretic peptide (NT?proBNP) for predicting silent myocardial ischaemia in type 2 diabetes mellitus independent of microalbuminuria
(Source: Diabetes/Metabolism Research and Reviews)
A novel biphenyl compound, VMNS2e, ameliorates streptozotocin induced diabetic nephropathy in rats
(Source: Journal of Diabetes)
Obesity and diabetes genetic variants associated with gestational weight gain
Conclusion: We found evidence that diabetes and obesity risk alleles interact with maternal pregravid body mass index to predict gestational weight gain. (Source: American Journal of Obstetrics and Gynecology)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
BASIC SCIENCE RESEARCH?Original Articles: Effects of Diabetes Mellitus on VEGF?Induced Proliferation Response in Bone Marrow Derived Endothelial Progenitor Cells
Abstract (Source: Journal of Cardiac Surgery)
Stem cell approaches for the treatment of type 1 diabetes mellitus.
This article reviews the different approaches that are being taken to produce new b cells. Much emphasis has been placed on selecting the right non-b cell population, either in vivo or in vitro, as the starting material. Different cell types, including adult stem cells, other types of progenitor cells in situ, and even differentiated cell populations, as well as embryonic stem cells and induced pluripotent stem cells, will require different methods for islet and b cell induction. We discussed the pros and cons of the different strategies that are being used to re-invent the pancreatic b cell.
PMID: 20801414 [PubMed - as supplied by publisher] (Source: Translational Research : the journal of laboratory and clinical medicine)
Alkem Lab develops low-cost sweetener
Alkem Laboratories has developed a low-cost sweetener that can be a game changer in the market which houses the most number of diabetes patients in the world. (Source: The Economic Times Healthcare and Biotech News)
Alkem Lab develops low-cost sweetener
Alkem Laboratories has developed a low-cost sweetener that can be a game changer in the market which houses the most number of diabetes patients in the world. (Source: The Economic Times Healthcare and Biotech News)
High-Fat Diet During Puberty Linked to Breast Cancer Risk Later in Life
August 31, 2010 (EurekAlert) - Girls eating a high-fat diet during puberty, even those who do not become overweight or obese, may be at a greater risk of developing breast cancer later in life, according to Michigan State University researchers.
The implications - that a high-fat diet may have detrimental effects independent of its effect to cause obesity - could drive new cancer prevention efforts.
read more (Source: Diabetes News from dLife.com)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
Obesity, Diabetes Epidemics Continue to Grow in California, UCLA Study Finds
August 31, 2010 (EurekAlert) - A majority of adults in California are obese or overweight, and more than 2 million have been diagnosed with diabetes, according to a new study from the UCLA Center for Health Policy Research.
Both conditions ? which are related to each other as well as to heart disease ? increased significantly in just six years, with the prevalence of diabetes alone jumping nearly 26 percent between 2001 and 2007.
read more (Source: Diabetes News from dLife.com)
LEDs Illuminate Eye for Ocular Disease Screening
August 31, 2010 (EurekAlert) - A new imaging system using six different wavelengths to illuminate the interior of the eyeball (ocular fundus) may pave the way for doctors to easily screen patients for common diseases of the eye, such as age-related macular degeneration and diabetic retinopathy. The system is described in the journal Review of Scientific Instruments, which is published by the American Institute of Physics.
read more (Source: Diabetes News from dLife.com)
Scientists Discover New Protein That Gets to the Roots of Obesity and Osteoporosis
August 31, 2010 (EurekAlert) - Here's good news for anyone trying to lose weight or has osteoporosis: Scientists from Maine are on the trail of a weight loss drug that may revolutionize how we treat these two conditions. In a new research report published in the September 2010 print issue of The FASEB Journal, the researchers describe a newly discovered protein, called "Sprouty," responsible for regulating body fat and bone mass.
read more (Source: Diabetes News from dLife.com)
Humanized nonobese diabetic-scid IL2r{gamma}null mice are susceptible to lethal Salmonella Typhi infection [Microbiology]
Salmonella enterica serovar Typhi, the cause of typhoid fever, is host-adapted to humans and unable to cause disease in mice.... (Source: Proceedings of the National Academy of Sciences)
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These Is What Candida Yeast Infection Is All About By Muna wa Wanjiru Candida yeast infection presents itself in several ways. It may cause redness and scaling on the skin usually accompanied with itching. Candida infection is caused by a yeast called Candida albicans. The use of antibiotics can cause the infection. Yeast is normally present on the skin of many people and due to several factors some people tend to get the infections more than others. People who suffer from tend to be more prone to Candida yeast infection. The Candida rash is also called monilia. The yeast will grow in the warm and moist areas and they include under the breast, arm pits, stomach and other skin folds. The condition can be treated very easily and you need to consult your doctor about this. You can apply a natural healer like heal Candida and the other treatment you can apply is hydrocortisone cream or ointment. The cream can be bought without a prescription. If you have a problem that keeps recurring, you should have a medical test to rule out a form of diabetes. Pills are sometimes taken for resistant cases and they are not recommended for everyone because they come with side effects. Even if you have and the condition keeps recurring, you should get your blood sugar under proper control and this may mean having a doctor reevaluate your treatment. Therefore, you should get Candida yeast infection of the skin under control with all the treatment options available. Another kind of common Candida yeast infection is of the vagina and is known as candidiasis. There is usually a fair number of yeast cells in the vagina and when this number goes up then, there is a likelihood
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that there will be Candida yeast infection. The signs of yeast infection in the vagina are usually itching, irritation and pain. The causes of the infection in women is the use of antibiotics. Another cause is the use of birth control pills and a woman can look into other methods of birth control. Pregnancy will cause hormonal imbalances and this in turn will cause the infection. Another thing that causes hormonal imbalance, is menopause and women at this stage in life will often complain of such infections. The thin vaginal walls during menopause will only contribute to the infection.
There are so many remedies for the disease and the most common are natural remedies. They involve the use natural healers like yogurt, tea tree oil, honey, vineager and so many others. The modern medicines are easy to administer and they include oral drugs for the vaginal infections. There are creams and ointments to apply in and around the vagina and they are usually very effective. There are several precautions that you can take to ensure that you avoid an infection and one of them is avoiding birth control pills that may cause the infection. Avoid antibiotics if you can and have the doctor recommend something more safe. Avoid damp cloths because the Candida loves such atmospheres and when you sweat, take a shower and dry your body completely.Article Directory: http://www.articlecube.com Peter Gitundu is a web administrator and has been researching and reporting on Yeast Infection for years. For more information on Candida Yeast Infection, visit his site at Candida Yeast Infection You Can Also Post Pour Views About Candida Yeast Infection On My Blog Here Candida Yeast Infection 
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Enough Sleep, Exercise, And Healthy Diabetic Recipe Can Help You Away From Diabetes
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Learning to deal with diabetes is never simple. It is bad enough we have to live in a greed-based world filled with anxiousness, violence, media junk, and the like. However, those with diabetes Read more...
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Could you have diabetic kidney disease and not even know it?
Questions to ask your doctor.
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Diabetes is the leading cause of chronic kidney disease
Chronic kidney disease (CKD) is on the rise in part because diabetes is on the rise. If you are at risk for diabetes or have been recently diagnosed with the disease, here’s what you should know about the link between diabetes and CKD.
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Diabetes and minorities: What are the risks?
 Some ethnic groups develop diabetes at two to six times the rate of whites. If you are African American, Hispanic, Native American, Asian or Pacific Islander, here’s what you should know about your risk for diabetes.]]>
Preventing chronic kidney disease when you have diabetes
Diabetes is the leading cause of chronic kidney disease. Keeping diabetes in check and early diagnosis of kidney disease could help decrease the chances of developing kidney failure.
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Diet tips for diabetics with kidney disease
 When diabetes leads to kidney disease the goal is to preserve kidney function as long as possible and manage diabetes. What you eat can affect both your blood sugar and your kidney function. A dietitian will work with you to create an eating plan that's right for you, probably using some of the diet tips presented here.]]>
Introduction
Diabetes: definition, causes and symptoms
For a while now, a?leading topic in the United States has been?about the growing number of people?diagnosed with diabetes. But what exactly is diabetes? Here you'll find the definition, causes and signs of diabetes. ]]>
Controlling diabetes
Diabetes is the leading cause of chronic kidney disease in the United States. By controlling diabetes through lifestyle choices such as diet and exercise, taking prescribed medicines and seeing a doctor regularly, people with diabetes can usually maintain a healthy lifestyle and help prevent chronic kidney disease and kidney failure. Find out what you can do to control diabetes.]]>
Diabetes and chronic kidney disease
Diabetes is the leading cause of chronic kidney disease in America. Many people with diabetes are not aware that chronic kidney disease can lead to kidney failure. However, having diabetes does not necessarily mean you will have kidney failure. Learn about the diabetes and kidney disease connection and how you can keep your kidneys healthy. ]]>
Preventing diabetic kidney disease
All about diabetes
Preventing diabetic kidney disease
How can I slow the progression of kidney disease?
Keeping healthy is the most important part of delaying kidney disease. If you have diabetes and have been diagnosed with an early stage of chronic kidney disease, following your doctor?s instructions regard]]>
Get the facts
Are you in control of your diabetes?
If you have diabetes, your doctor advises you to keep your glucose levels in a healthy range. One of the problems that can occur for diabetics who don’t control their diabetes is the risk of kidney disease which may lead to kidney failure and dialysis. Diabetes is the leading cause of kidney disease in America. Learn how you can control your diabetes to avoid other health complications such as renal disease.
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Diabetic nephropathy
Diabetic nephropathy means kidney damage that occurs as a result of diabetes. Researchers believe poor control of blood sugar or blood glucose levels is one of the reasons people with diabetes develop this type of kidney disease. Learn about diabetic nephropathy symptoms, diagnosis and treatment.
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Diabetes and peritoneal dialysis
 Diabetes mellitus is the number one cause of kidney failure in the United States, leading many people to need dialysis. Learn about the relationship between diabetes and chronic kidney disease (CKD), as well as how people with diabetes can choose to do the home dialysis treatment, peritoneal dialysis (PD).]]>
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Type 2 Diabetes
By Juliet
Type 2 diabetes is the most common form of diabetes. Type 2 Diabetes is a metabolic disorder that is primarily characterized by insulin resistance, Read more...
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