Beware Of Kids That Have Signs Of Heart Disease!
By Ng Peng Hock
Under normal circumstances, we would think that only adults, especially elderly, will have narrowing and hardening of arteries. But, the findings of a study presented at the annual American Heart Association in Chicago last month (Nov 2006) will probably change our views.

A group of researchers in Canada, Finland, Australia, the United States, Norway, Italy, and Netherlands found that children with risk factors for heart disease, including high cholesterol and diabetes, are now showing signs of heart disease, including hardened of blood vessels and arterial wall thickness. The report revealed that in 12 of the 15 studies examined, children with risk factors were more likely to have increased thickness in the arterial walls, which could lead to heart attacks in adulthood. The risk factors include familial hypercholesterolemia where children whose defective genes causes high cholesterol levels in them, diabetes, obesity, and genetic factors.

Some experts and doctors felt that the finding is probably not new as previous postmortem studies of young United States soldiers who died in the Korean War had shown atherosclerotic changes in their arteries. The process must have begun much earlier on in their life. It is evident that deposits of plaque containing cholesterol and lipids takes years to build up and risk factors in childhood hasten the process.

There is indication that the number

Effects of exercise combined with caloric restriction on inflammatory cytokines
Jennifer L. Reed, Mary Jane De Souza, and Nancy I. Williams - Chronic inflammation has been implicated in the pathogenesis of several chronic diseases, such as atherosclerosis and diabetes, as well as certain types of cancers. It... (Source: Applied Physiology, Nutrition, and Metabolism)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
Clinical characteristics and evolution of non-HIV-infected immunocompromised patients with an in-hospital diagnosis of tuberculosis
CONCLUSIONS: The lower prevalence of classic symptoms, the occurrence of extrapulmonary tuberculosis, the delayed initiation of treatment, and the high mortality rate reflect the diagnostic and therapeutic challenges of tuberculosis in non-HIV-infected immunocompromised patients. (Source: Jornal Brasileiro de Pneumologia)
Aminoguanidine reduces oxidative stress and structural lung changes in experimental diabetes mellitus
Avaliamos o efeito da aminoguanidina sobre o estresse oxidativo pulmonar e a estrutura pulmonar em um modelo experimental de diabetes mellitus. Foram determinados thiobarbituric acid reactive substances (TBARS, substâncias reativas ao ácido tiobarbitúrico), histologia e gasometria arterial em animais com diabetes mellitus (DM), animais com diabetes mellitus tratados com aminoguanidina (DM+AG) e controles. O nível de TBARS foi significativamente maior no grupo DM que nos grupos controle e DM+AG (2,90 ± 1,12 vs. 1,62 ± 0,28 e 1,68 ± 0,04 nmol/mg proteína, respectivamente), o mesmo ocorrendo com PaCO2 em relação ao grupo controle (49,2 ± 1,65 vs. 38,12 ± 4,85 mmHg), e PaO2 foi significativamente maior no grupo controle (104,5 ± 6,3 vs. 69,48 ±16,30 e 97,05 ± 14,02 mmHg, respect...
Strategies for Preventing Diabetes
Being diagnosed with pre-diabetes does not automatically sentence you to a life of insulin injections and blood glucose tests. In most cases, the power to prevent diabetes from progressing is completely up to you. Life-Changing Lifestyle Changes Elisabetta Politi, RD, MPH, CDEElisabetta Politi, RD, MPH, CDE, nutrition director at the Duke Diet & Fitness Center, says people who are pre-diabetic can reduce the risk of diabetes by 55 percent if they adopt a healthy lifestyle that includes eating a good diet and exercise. This lifestyle change is even more effective in preventing the onset of diabetes than the use of medication. Politi encourages people not to focus on losing massive amounts of weight. Even moderate weight loss of 7 to 10 percent will dramatically improve your chances of ...
Inhibition of inducible nitric oxide synthase reverses the loss of functional hyperemia in diabetic retinopathy
Abstract (Source: Glia)
Santarus Licenses Novel Type 2 Diabetes Drug CYCLOSET
Santarus, Inc. (NASDAQ: SNTS), S2 Therapeutics, Inc. and VeroScience LLC today announced that they have entered into a distribution and license agreement granting Santarus exclusive rights to manufacture and commercialize CYCLOSET® (bromocriptine mesylate) tablets in the U.S. CYCLOSET is a prescription drug approved by the U.S. Food and Drug Administration (FDA) as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus both as mono-therapy and in combination with other oral antidiabetic agents... (Source: Health News from Medical News Today)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
Centre To Give New Dimension To Fight Against Disease
New facilities opening tomorrow will help scientists in York develop drugs and vaccines to combat chronic diseases that devastate the lives of millions of people across the world. The new £5m home for the Centre for Immunology and Infection (CII) will help researchers to make an important contribution to international efforts to better understand some of the world's most important chronic diseases, and develop strategies for prevention and cure. In developed countries, lives are severely debilitated by Crohn's Disease, diabetes and HIV/AIDS... (Source: Health News from Medical News Today)
Restrictive lung function linked to Type 2 diabetes and fatal CHD
Researchers report that restrictive impairment of lung function, as indicated by low forced vital capacity and forced expiratory volume in 1 second, is associated with increased risk for incident Type 2 diabetes and fatal coronary heart disease in middle-aged men. (Source: MedWire News - Diabetes)
The Safety Questioned Of Certain 'Healthful' Plant-Based Antioxidants
Scientists are calling for more research on the possibility that some supposedly healthful plant-based antioxidants - including those renowned for their apparent ability to prevent cancer - may actually aggravate or even cause cancer in some individuals. Their recommendation follows a study in which two such antioxidants - quercetin and ferulic acid - appeared to aggravate kidney cancer in severely diabetic laboratory rats. The study appears in ACS' bi-weekly Journal of Agricultural and Food Chemistry... (Source: Health News from Medical News Today)
Several Inflammatory Factors Induced By Bacterial Infection May Be Reduced By Insulin
Treating intensive care patients who develop life-threatening bacterial infections, or septicemia, with insulin potentially could reduce their chances of succumbing to the infection, if results of a new preliminary study can be replicated in a larger study. A paper published online ahead of print in Diabetes Care reports that insulin lowered the amount of inflammation and oxidative stress in study participants who had been injected with a common bacteria, or endotoxin, known as LPS (lipopolysaccharide)... (Source: Health News from Medical News Today)
NICE Issues Its Final Appraisal Determination (FAD) On The Use Of Victoza(R) (liraglutide) For People With Type 2 Diabetes In The UK
Today, as part of its Single Technology Appraisal (STA), the National Institute for Health and Clinical Excellence (NICE), issued its Final Appraisal Determination (FAD) on the use of Victoza® (liraglutide)1 for patients with type 2 diabetes in the UK. It is anticipated final guidance will be made public in October 2010 and once published primary care trusts (PCTs) must find funding for liraglutide within three months of publication for the appropriate patients as indicated by the guidance... (Source: Health News from Medical News Today)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
Liraglutide (Victoza) For Diabetes Type Two Approved For The NHS, UK
The National Institute for Clinical Excellence (NICE), in a draft guidance has recommended Liraglutide (Victoza) 1.2mg injectable daily for some patients with diabetes mellitus type 2. NICE does not, however, recommend the 1.8mg daily dosage, saying there does not appear to be any significant additional benefit over the 1.2mg dose. NICE recommends Liraglutide 1... (Source: Health News from Medical News Today)
The daily jab that combats diabetes: Treatment also helps patients shed the pounds
The injection, called Victoza, has been given the go-ahead by the drugs watchdog, the National Institute for Health and Clinical Excellence. (Source: the Mail online | Health)
Study Finds Obesity Determined By Brain Cells -- Not Lack Of Willpower
An international study has discovered the reason why some people who eat a high-fat diet remain slim, yet others pile on the weight. The study, led in Australia by the Monash Obesity and Diabetes Institute (MODI) at Monash University, found a high-fat diet causes brain cells to become insulated from the body preventing vital signals, which tell the body to stop eating and to burn energy, from reaching the brain efficiently. MODI director and Australian Life Scientist of the Year Professor Michael Cowley said there were two clear outcomes from the findings... (Source: Health News from Medical News Today)
How Insulin Stimulates Fat Cells To Take In Glucose
Using high-resolution microscopy, researchers at the National Institutes of Health have shown how insulin prompts fat cells to take in glucose in a rat model. The findings were reported in the Sept. 8 issue of the journal Cell Metabolism. By studying the surface of healthy, live fat cells in rats, researchers were able to understand the process by which cells take in glucose. Next, they plan to observe the fat cells of people with varying degrees of insulin sensitivity, including insulin resistance - considered a precursor to type 2 diabetes... (Source: Health News from Medical News Today)
Oxidation-Specific Biomarkers, Lipoprotein(a), and Risk of Fatal and Nonfatal Coronary Events
Conclusions: This EPIC-Norfolk study links pathophysiologically related oxidation-specific biomarkers and Lp(a) with CAD events. Oxidation-specific biomarkers provide cumulative predictive value when added to traditional cardiovascular risk factors. (Source: Journal of the American College of Cardiology)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
The addition of pioglitazone in type 2 diabetics poorly controlled on insulin therapy: A meta-analysis.
CONCLUSIONS: Our study implied that in patients with type 2 DM whose control is inadequate on insulin therapy, the additional pioglitazone could significantly improve glucose metabolism and might have a positive effect on important components of the lipid profile, which may have important implications in reducing the risk of cardiovascular disease, a major long-term complication in type 2 diabetes mellitus. Besides, the adverse events (AEs) were well tolerated. PMID: 20816593 [PubMed - in process] (Source: European Journal of Internal Medicine)
Impact of exercise intensity and duration on insulin sensitivity in women with T2D.
CONCLUSION: Improvement in insulin sensitivity after six months combined supervised group training in female diabetic subjects is related to exercise intensity, whereas the reduction in HbA1c is related mainly to training volume. Metabolic effects of training may be seen in the absence of improved exercise capacity. PMID: 20816594 [PubMed - in process] (Source: European Journal of Internal Medicine)
Mild heart failure is a mortality marker after a non-ST-segment acute myocardial infarction.
CONCLUSION: Mild HF at presentation in NSTEMI is linked to a poor prognosis, with increased short-term mortality. Thus, a more aggressive approach including early cardiac catheterization and revascularization should be considered. PMID: 20816601 [PubMed - in process] (Source: European Journal of Internal Medicine)
Ontario's Population Mostly Overweight and Obese
Overweight and obese make up majority in Ontario - Heart Institute study finds strong link to high blood pressure, diabetes. (Source: Disabled World)
NICE backs liraglutide for diabetes
NICE has approved the GLP-1 analogue liraglutide for the treatment of some type-2 diabetes patients. (Source: HealthcareRepublic Independent Nurse News)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
Impact of Angiotensin-Converting Enzyme Inhibitors Administration Prior to Acute Ischemic Stroke Onset on In-Hospital Mortality
Conclusion: This study provides evidence that the prophylactic administration of ACEI before ischemic stroke may be a potential life-saving strategy. Furthermore, knowledge of in-hospital mortality predictors is necessary to improve survival rate after acute stroke. (Source: Journal of Cardiovascular Pharmacology and Therapeutics)
Evaluation of Antihypertensive Therapy Among Ischemic Stroke Survivors: Impact of Ischemic Heart Disease
Conclusion: Patterns of antihypertensive therapy were commonly but not adequately consistent with international guidelines. Screening stroke survivors for blood pressure control, initiating appropriate antihypertensive medications, and decreasing the number of untreated patients might help reduce the risk of recurrent strokes and increase survival. (Source: Journal of Cardiovascular Pharmacology and Therapeutics)
Long-Term Weight Loss May Be Harmful to Health
Long-term weight loss may release into the blood industrial pollutants linked to illnesses like diabetes, hypertension and rheumatoid arthritis, researchers said on Tuesday. Reuters Health Information (Source: Medscape Diabetes Headlines)
Medical bracelets: Not just bling when connected to PHRs
Source: Don Fluckinger, Health IT Pulse Content: &#8220;Between now and when we all have RFID chips embedded under our skin relaying medical information pertinent in emergencies, such as penicillin allergies, heart conditions, diabetes and prescription histories, medical bracelets remain the main way to communicate with emergency responders when a patient is unconscious or otherwise [...] (Source: ICMCC: The International Council on Medical and Care Compunetics)
A cognitive-behavioural pedometer-based group intervention on physical activity and sedentary behaviour in individuals with type 2 diabetes
The purpose of this study was to investigate the benefits of a pedometer and a cognitive-behavioural group intervention for promoting physical activity (PA) in type 2 diabetes patients. We recruited 41 participants and randomized them into an intervention group (IG) (n = 20) and a control group (CG) (n = 21). The intervention consisted of five sessions within 12 weeks, a booster session after 22 weeks and a pedometer. Primary outcome was PA assessed by accelerometer (minutes per day) and pedometer (steps per day). Secondary outcomes were weight, body mass index, blood pressure, haemoglobin A1c and total cholesterol. After 12 weeks, the IG increased with more than 2000 steps day&ndash;1 compared with the CG, whereas sedentary behaviour decreased more than 1 hour day&ndash;1 in the IG and sh...<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
Study Finds Bariatric Surgery Lowers Gestational Diabetes Risk
But weight loss procedure has its own set of risks, experts note (Source: The Doctors Lounge - Health News)
Congratulations To Express Outreach Awardees!
The NN/LM Pacific Northwest Region is pleased to announce two new Express Outreach Projects underway by the Northwest Regional Primary Care Association (NWRPCA) and the Multimedia Resources and Training Institute (MMRTI). Community Health Worker Outreach and Training Program &#8211; Northwest Regional Primary Care Association The goal of this project is to increase Community Health Workers&#8216; familiarity, understanding and use of online health information resources.  By doing so, Community Health Workers will be able to effectively access resources, thereby bolstering their ability to communicate critical health information to the populations they serve.  The recognized value of Community Health Worker services will increase, which will help them become more fully integrated into the...
Free E-book for September
Jefferson students, faculty and staff qualify for a free download of Psychiatry Online&#8217;s featured book each month. September&#8217;s free download is Managing Metabolic Abnormalities in the Psychiatrically Ill, edited by Richard A. Bermudes, MD, Paul E. Keck, Jr., MD, and Susan L. McElroy, MD. From the publisher&#8217;s description: Patients with mental and substance use disorders have shown higher rates of morbidity and mortality from medical illnesses than the general population, and physicians are also increasingly aware of adverse effects of psychiatric medications on metabolic and cardiovascular health. In light of these problems, this book addresses an important unmet need of patients with mental disorders-namely, the lack of integration of general medical care with psychiatric...
What Do Patients Hear When You Say "Diabetes"?
A play performed at the annual meeting of the American Diabetes Association portrays the world of a patient with newly diagnosed type 2 diabetes. Medscape Diabetes & Endocrinology (Source: Medscape Today Headlines)
Appetite Hormones May Predict Weight Regain after Dieting
September 7, 2010 (Newswise) - Many people have experienced the frustration that comes with regaining weight that was lost from dieting. According to a new study accepted for publication in The Endocrine Society?s Journal of Clinical Endocrinology & Metabolism (JCEM), the levels of appetite hormones in the body prior to dieting may serve as a predictor of weight regain after dieting. read more (Source: Diabetes News from dLife.com)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
New Childhood Obesity Journal Launched By Mary Ann Liebert Inc., Publishers
Publisher Mary Ann Liebert announced the launch of Childhood Obesity to provide physicians, nurses, dietitians, diabetes educators, nutritionists, psychologists, educators and school nurses, community organizers, and policymakers with effective prevention and treatment strategies that promote environmental and policy changes, patient education and motivation tools, and clinical advances in the field. The Journal, which is an outgrowth of Obesity and Weight Management, has a very broad mission to be the premier journal and central forum on childhood and adolescent obesity... (Source: Health News from Medical News Today)
TRAQ-D (Trinidad Risk Assessment Questionnaire for Type 2 Diabetes Mellitus): A Cheap, Reliable, Non-invasive Screening Tool for Diabetes
A culturally sensitive questionnaire was used to assess risk for type 2 diabetes in Trinidad. The British Journal of Diabetes and Vascular Disease (Source: Medscape Today Headlines)
Mitochondrial morphology and cardiovascular disease
Mitochondria are dynamic and are able to interchange their morphology between elongated interconnected mitochondrial networks and a fragmented disconnected arrangement by the processes of mitochondrial fusion and fission, respectively. Changes in mitochondrial morphology are regulated by the mitochondrial fusion proteins (mitofusins 1 and 2, and optic atrophy 1) and the mitochondrial fission proteins (dynamin-related peptide 1 and mitochondrial fission protein 1) and have been implicated in a variety of biological processes including embryonic development, metabolism, apoptosis, and autophagy, although the majority of studies have been largely confined to non-cardiac cells. Despite the unique arrangement of mitochondria in the adult heart, emerging data suggest that changes in mitochondria...
The SR-mitochondria interaction: a new player in cardiac pathophysiology
Mitochondria are essential for energy supply and cell signalling and may be triggers and effectors of cell death. Mitochondrial respiration is tightly controlled by the matrix Ca2+ concentration, which is beat-to-beat regulated by uptake and release mainly through the mitochondrial Ca2+ uniporter and Na+/Ca2+ exchanger, respectively. Recent studies demonstrate that mitochondrial Ca2+ uptake is more dependent on anatomo-functional microdomains established with the sarcoplasmic reticulum (SR) than on cytosolic Ca2+. This privileged communication between SR and mitochondria is not restricted to Ca2+ but may involve ATP and reactive oxygen species, which has important implications in cardiac pathophysiology. The disruption of the SR&ndash;mitochondria interaction caused by cell remodelling has...
Nursing failures led to Staffordshire death
A systematic failing to provide adequate nursing facilities, combined with low staffing levels, contributed to the death of a 66-year-old diabetic at a Staffordshire hospital, an inquest jury has ruled. (Source: Nursing Times Breaking News)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
Obesity, Diabetes Increasingly Common in Region
Most California adults are obese or overweight, and more than 2 million have been diagnosed with diabetes, [a new] study reveals. Both conditions increased significantly in just six years, with the prevalence of diabetes alone jumping nearly 26 percent statewide between 2001 and 2007, the study shows. (Source: RWJF News Digest - Childhood Obesity)
How insulin stimulates fat cells to take in glucose
Using high-resolution microscopy, researchers have shown how insulin prompts fat cells to take in glucose in a rat model. By studying the surface of healthy, live fat cells in rats, researchers were able to understand the process by which cells take in glucose. Next, they plan to observe the fat cells of people with varying degrees of insulin sensitivity, including insulin resistance-considered a precursor to type 2 diabetes. These observations may help identify the interval when someone becomes at risk for developing diabetes. (Source: ScienceDaily Headlines)
Endovascular Repair of Carotid Artery Pseudoaneurysm After Carotid Endarterectomy With Self-Expanding Covered Stents?A Long-Term Follow-Up
A 66-year-old Caucasian man with type 2 diabetes mellitus, peptic ulcer disease, peripheral vascular disease, and a 70% symptomatic carotid stenosis underwent a successful carotid endarterectomy with intraoperative shunting and Dacron patch closure in October 2000. Three months later, he developed a pseudoaneurysm at the site of the surgical repair. This was successfully treated with endovascular covered stents and has continued to remain patent at 9-year follow-up. Carotid artery pseudoaneurysms are secondary to trauma, infection, or previous surgery. Open surgical repair has been the treatment of choice for these pseudoaneurysms. However, open repairs are difficult and carry a high morbidity. Thus, endovascular therapy is a valid treatment for carotid artery pseudoaneurysm. Reviewing the...
Batroxobin for Prevention of Restenosis in Diabetic Patients After Infrapopliteal Arterial Angioplasty: A Small Randomized Pilot Trial
Conclusion: This pilot trial revealed that batroxobin usage was effective in preventing restenosis and reocclusion after infrapopliteal arterial angioplasty, and it might provide better clinical symptoms relief; however, it did not report preferable limb salvage or amputation-free rates. (Source: Annals of Vascular Surgery)
Chronic age-related diseases share risk factors: do they share pathophysiological mechanisms and why does that matter?
Authors: Probst-Hensch NM The World Health Organization (WHO) assigns high priority to the prevention of non-communicable age-related diseases such as heart disease, cancer, diabetes, stroke and chronic lower respiratory diseases. They are now the leading causes of death, in both industrialised and developing countries, mostly due to increased life expectancy and urbanisation with associated changes in lifestyle and environment. Tobacco smoking, physical inactivity and resulting obesity are established risk factors for many chronic diseases. Yet, the aetiology of age-related diseases is complex and varies between individuals. This often makes it difficult to identify causal risk factors, especially if their relative effects are weak. For example, the associations of both obesity and ai...<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
Impact of a normal or non-specific admission ECG on the treatment and early outcome of patients with myocardial infarction in Swiss hospitals between 2003 and 2008.
CONCLUSIONS: Despite less intensive treatment, AMI patients who presented with a normal/non-specific ECG developed cardiogenic shock less frequently during their hospitalisation and had a lower crude mortality rate compared to those with ECG changes on admission. Nevertheless, reinfarctions and cerebrovascular events occurred evenly in all AMI patients, regardless of their admission ECG. PMID: 20799102 [PubMed - in process] (Source: Swiss Medical Weekly)
The clinical and laboratory importance of mean platelet volume
Os índices plaquetários fornecidos pelos analisadores hematológicos são provavelmente os parâmetros mais ignorados pela maioria dos laboratórios clínicos, em virtude da dificuldade de sua padronização. Desses índices, o volume plaquetário médio (VPM) vem merecendo destaque por sua grande utilidade, não só em casos de trombose e hemostasia, mas também em uma série de patologias, como diabetes, doenças da tireoide, doenças vasculares, entre outras. O VPM é um parâmetro plaquetário fornecido no hemograma que não gera custos adicionais para o laboratório. Junto com a contagem de plaquetas, ele é um sensível indicador de desordens plaquetárias in vivo, mas pode ser tecnicamente difícil de analisá-lo in vitro por causa dos interferentes pré-analíticos, como tempo de...
Insulin Implicated In Cell Survival, Cell Metabolism And Stress Response
Researchers at the Buck Institute for Age Research have discovered a novel way in which insulin affects cell metabolism and cell survival. Surprisingly the insulin signaling pathway, which is involved in aging, diabetes and stress response, is active at a deeper level of cell activity than scientists expected. The study appears in the September 8th issue of Cell Metabolism. Insulin is vitally involved in many cell functions... (Source: Health News from Medical News Today)
Risk Of Gestational Diabetes, Cesarean Section, Reduced In The Obese By Bariatric Operations
Obese women who have bariatric surgical procedures before pregnancy were three times less likely to develop gestational diabetes (GDM) than women who have bariatric operations after delivery, according to new research findings published in the August issue of the Journal of the American College of Surgeons. The retrospective study also found that delivery after bariatric procedures was associated with reduced odds of cesarean section - an outcome associated with GDM... (Source: Health News from Medical News Today)
Solving The Problem Of Cell Death Aids Stem Cell Research
Human pluripotent stem (hPS) cells can generate any given cell type in the adult human body, which is why they are of interest to stem cell scientists working on finding therapies for spinal cord injuries, Parkinson's disease, burns, heart disease, diabetes, arthritis, and other ailments. Before hPS cell technologies can be translated into clinical applications, however, some obstacles must first be overcome... (Source: Health News from Medical News Today)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
Immune System Genes Show Links to Type 1 Diabetes
Title: Immune System Genes Show Links to Type 1 DiabetesCategory: Health NewsCreated: 9/8/2010 2:10:00 PMLast Editorial Review: 9/9/2010 (Source: MedicineNet Diabetes General)
Dementia Warning Signs Identified in Type 2 Diabetics: Study
Title: Dementia Warning Signs Identified in Type 2 Diabetics: StudyCategory: Health NewsCreated: 9/8/2010 4:10:00 PMLast Editorial Review: 9/9/2010 (Source: MedicineNet Diabetes General)
Dementia Warning Signs Identified in Type 2 Diabetics: Study
Title: Dementia Warning Signs Identified in Type 2 Diabetics: StudyCategory: Health NewsCreated: 9/8/2010 4:10:00 PMLast Editorial Review: 9/9/2010 (Source: MedicineNet Alzheimer)
Immune System Genes Show Links to Type 1 Diabetes
Title: Immune System Genes Show Links to Type 1 DiabetesCategory: Health NewsCreated: 9/8/2010 2:10:00 PMLast Editorial Review: 9/9/2010 (Source: MedicineNet Senior Health General)
Dementia Warning Signs Identified in Type 2 Diabetics: Study
Title: Dementia Warning Signs Identified in Type 2 Diabetics: StudyCategory: Health NewsCreated: 9/8/2010 4:10:00 PMLast Editorial Review: 9/9/2010 (Source: MedicineNet Senior Health General)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
Ghrelin suppresses insulin secretion in healthy nondiabetics
Results from a proof-of-concept study show that ghrelin reduces glucose-stimulated insulin secretion and subsequently lowers plasma glucose in healthy nondiabetic individuals. (Source: MedWire News - Diabetes)
Pathophysiology of Diabetes Mellitus in Cushing’s Syndrome
Neuroendocrinology 2010;92(suppl 1):77–81 (DOI:10.1159/000314319) (Source: Karger Publishers)
Management of Diabetes Mellitus in Cushing’s Syndrome
Neuroendocrinology 2010;92(suppl 1):82–85 (DOI:10.1159/000314316) (Source: Karger Publishers)
Sleep less than 6 hours ups diabetes risk
WARWICK, England, Sept. 9 (UPI) -- People who sleep less than 6 hours a night aren't able to regulate glucose efficiently, increasing the risk of heart disease, British and U.S. researchers say. Heart disease - Diabetes mellitus - Health - Conditions and Diseases - United States (Source: Health News - UPI.com)
Selective whole blood lipoprotein apheresis to prevent pancreatitis in drug refractory hypertriglyceridemia.
CONCLUSIONS: Triglyceride levels were lowered after initiating selective lipoprotein apheresis. More importantly, the patient did not experience any relapses of pancreatitis after the treatment was started. Hence this treatment is feasible in drug refractory hypertiglyceridemia, but the treatment concept needs to be tested in additional studies. PMID: 20818118 [PubMed - in process] (Source: JOP)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
UK Experts Advised Rosiglitazone Withdrawal in July
It has emerged this week that UK experts recommended the withdrawal of the diabetes drug rosiglitazone from the British market in July, although this recommendation was not made public at the time. Heartwire (Source: Medscape Today Headlines)
Moderate coffee and alcohol intake may reduce risk for Type 2 diabetes
Results from the Black Women?s Health Study suggest that consumption of moderate amounts of caffeinated coffee and alcohol may reduce the risk for developing Type 2 diabetes. (Source: MedWire News - Diabetes)
Saxagliptin noninferior to sitagliptin for treating Type 2 diabetes
Saxagliptin is noninferior to sitagliptin for the treatment of Type 2 diabetes when added to metformin therapy, show study results. (Source: MedWire News - Diabetes)
Ambient Particulate Matter as a Risk Factor for Suicide [Articles]
Conclusions: Conclusions: A transient increase in particulate matter was associated with increased suicide risk, especially for individuals with preexisting cardiovascular disease. (Source: Am J Psychiatry)
Clinical correlates of arterial lactate levels in patients with ST-segment elevation myocardial infarction at admission: a descriptive study
Conclusions: In STEMI patients, impaired hemodynamics, worse TIMI flow and non-smoking were related to increased arterial lactate levels. Higher lactate levels were independently related with 30-day mortality and an overall worse response to PCI. In particular, acute mortality was related to admission lactates [greater than or equal to] 1.8 mmol/L. Point-of-care measurement of arterial lactate at admission in patients with STEMI has the potential to improve acute risk stratification. (Source: Critical Care)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
Synergism in hyperhomocysteinemia and diabetes: role of PPAR gamma and tempol
Conclusions: Endogenous homocysteine exacerbates diabetic cardiomyopathy by attenuating PPAR gamma and inducing E-M uncoupling leading to diastolic dysfunction. PPAR gamma agonist and tempol mitigates oxidative stress and ameliorates diastolic dysfunction in diabetes. (Source: Cardiovascular Diabetology)
Impact of Age, Sex, and Comorbidity on Cancer Therapy and Disease Progression [REVIEW ARTICLES]
A theme of personalized medicine was highlighted at the 2009 Annual Meeting of the American Society of Clinical Oncology. To this end, the current review focuses on the impact of host characteristics (such as age, sex, and comorbidity) as they pertain to cancer biology, treatment efficacy, and tolerance. Increasing age is associated with complex changes in physiology, including alterations in renal and hepatic function, and decreased bone marrow reserve. These may in turn result in alterations in pharmacokinetics and toxicity related to many commonly used anticancer agents. Using tools, such as the geriatric assessment, may help to elucidate the physiologic age of the patient as opposed to the chronologic age. Increasing age is paralleled by an increase in comorbidity, and comorbidity may ...
Diagnosing Diabetes With HbA1c Leads to Racial Disparities
Efforts to adopt a more accurate test for diagnosing diabetes may have hit a snag. Comparing the oral glucose tolerance test to the hemoglobin (Hb)A1c test confirms earlier evidence that race may influence test results, Danish researchers report. Reuters Health Information (Source: Medscape Diabetes Headlines)
Exenatide and Sitagliptin Not Tied to Pancreatitis
Neither exenatide (Byetta) nor sitagliptin (Januvia) causes acute pancreatitis, according to a pharmacy claims analysis. Reuters Health Information (Source: Medscape Diabetes Headlines)
Diabetes could cost Ontario $7B by 2020
Diabetes could cost Ontario $7 billion a year by 2020 if action isn't taken now, says the Canadian Diabetes Association. (Source: CBC | Health)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
Dementia Warning Signs Identified in Type 2 Diabetics: Study
High blood pressure, slow gait, self-reported bad health might signal decline, researchers say (Source: The Doctors Lounge - Cardiology)
Questioning the safety of certain 'healthful' plant-based antioxidants
Scientists are calling for more research on the possibility that some supposedly healthful plant-based antioxidants -- including those renowned for their apparent ability to prevent cancer -- may actually aggravate or even cause cancer in some individuals. Their recommendation follows a study in which two such antioxidants -- quercetin and ferulic acid -- appeared to aggravate kidney cancer in severely diabetic laboratory rats. (Source: ScienceDaily Headlines)
Insulin May Reduce Several Inflammatory Factors Induced by Bacterial Infection
September 8, 2010 (EurekAlert) - Treating intensive care patients who develop life-threatening bacterial infections, or septicemia, with insulin potentially could reduce their chances of succumbing to the infection, if results of a new preliminary study can be replicated in a larger study. read more (Source: Diabetes News from dLife.com)
Dementia Warning Signs Identified in Type 2 Diabetics
High blood pressure, slow gait, self-reported bad health might signal decline, researchers say Source: HealthDay Related MedlinePlus Pages: Dementia, Diabetes (Source: MedlinePlus Health News)
UK experts advised rosiglitazone withdrawal in July
It has emerged this week that UK experts recommended the withdrawal of the diabetes drug rosiglitazone from the British market in July, although this recommendation was not made public at the time.... For complete story visit theheart.org. (Source: theHeart.org)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
Immune System Genes Show Links to Type 1 Diabetes
Finding is starting point for new work on the disease's origins, possible treatment, experts say (Source: The Doctors Lounge - Health News)
Eriobotryae Folium Extract Suppresses LPS-Induced iNOS and COX-2 Expression by Inhibition of NF-kappaB and MAPK Activation in Murine Macrophages.
In this study, we examined the effects of Eriobotryae folium extract (EFE) on lipopolysaccharide (LPS)-induced production of nitric oxide (NO) and prostaglandin E(2)(PGE(2)) in RAW264 murine macrophage cells. EFE suppressed LPS-induced NO and PGE(2) production in a dose-dependent manner. Consistent with these observations, EFE reduced the LPS-induced expressions of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) at both protein and mRNA levels. Furthermore, EFE significantly inhibited LPS-induced NF-kappaB binding activity, which was associated with the inhibition of IkappaB-alpha degradation. EFE also attenuated LPS-induced phosphorylation of mitogen-activated protein kinases (MAPKs) including extracellular signal-regulated kinase (ERK), p38 MAPK and c-Jun N-terminal k...
Immune System Genes Show Links to Type 1 Diabetes
Finding is starting point for new work on the disease's origins, possible treatment, experts say Source: HealthDay Related MedlinePlus Pages: Diabetes Type 1, Genes and Gene Therapy, Immune System and Disorders (Source: MedlinePlus Health News)
Abnormalities of serum potassium concentration in dialysis-associated hyperglycemia and their correction with insulin: review of published reports
Abstract&nbsp;&nbsp;The main difference between dialysis-associated hyperglycemia (DH) and diabetic ketoacidosis (DKA) or nonketotic hyperglycemia (NKH) occurring in patients with preserved renal function is the absence of osmotic diuresis in DH, which eliminates the need for large fluid and solute (including potassium) replacement. We analyzed published reports of serum potassium (K+) abnormalities and their treatment in DH. Hyperkalemia was often present at presentation of DH with higher frequency and severity than in hyperglycemic syndromes in patients with preserved renal function. The frequency and severity of hyperkalemia were higher in DH episodes with DKA than those with NKH in both hemodialysis and peritoneal dialysis. For DKA, the frequency and severity of hyperkalemia were ...
Macular edema and visual outcome following cataract surgery in patients with diabetic retinopathy and controls
Conclusion&nbsp;&nbsp;The final visual outcome in eyes with mild to moderate retinopathy, without previous ME, is as good as in normal eyes, but an increased frequency of macular changes may protract recovery of full vision. Changes on OCT or FA are often seen without any obvious effect on VA. OCT is as good as FA at detecting a clinical CME, and is the technique recommended for follow-up before FA is considered. Content Type Journal ArticleDOI 10.1007/s00417-010-1484-9Authors Urban Eriksson, Department of Neuroscience, Ophthalmology, Uppsala University, Akademiska sjukhuset, 751 85 Uppsala, SwedenAlbert Alm, Department of Neuroscience, Ophthalmology, Uppsala University, Akademiska sjukhuset, 751 85 Uppsala, SwedenGunilla Bjärnhall, Department of Neuroscience, Ophthalmology,...<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
NIH Study Shows How Insulin Stimulates Fat Cells to Take in Glucose
September 7, 2010 (EurekAlert) - Using high-resolution microscopy, researchers at the National Institutes of Health have shown how insulin prompts fat cells to take in glucose in a rat model. The findings were reported in the Sept. 8 issue of the journal Cell Metabolism. read more (Source: Diabetes News from dLife.com)
Brain Cells Determine Obesity -- Not Lack of Willpower: Study
September 8, 2010 (EurekAlert) - An international study has discovered the reason why some people who eat a high-fat diet remain slim, yet others pile on the weight. The study, led in Australia by the Monash Obesity and Diabetes Institute (MODI) at Monash University, found a high-fat diet causes brain cells to become insulated from the body preventing vital signals, which tell the body to stop eating and to burn energy, from reaching the brain efficiently. read more (Source: Diabetes News from dLife.com)
ACP Explores Ethical Issues for Use of Incentives to Promote Personal Responsibility for Health
September 8, 2010 (EurekAlert) - The American College of Physicians (ACP) today released a new position paper that provides ethical guidance for using incentives to promote personal responsibility for health. read more (Source: Diabetes News from dLife.com)
Reading Food Labels, Combined with Exercise, Can Lead to Weight Loss
September 8, 2010 (EurekAlert) - Nutritional science and food marketing has become so sophisticated in recent decades that a trip to the supermarket can require a complete nutritional re-education. The average consumer needs to be on guard against preservatives, added fat, colorings, and calories, false advertising, and sophisticated but misleading labels. read more (Source: Diabetes News from dLife.com)
Weight Loss Raises Industrial Pollutant Levels In Blood
People with long-term weight loss have higher levels of persistent organic pollutants in their blood, which are known to increase the risk of developing rheumatoid arthritis, high blood pressure (hypertension) and diabetes, according to an article published today in the International Journal of Obesity. Persistent organic pollutants (POPs) are organic compounds, they are resistant to environmental degradation - they do not break down easily, so they persist and build up in the environment. POPs can bioaccumulate (build up) in human and animal tissue, as well as food chains... (Source: Health News from Medical News Today)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
Diabetes could cost Ontario $7 billion a year by 2020
The Canadian Diabetes Association says if action isn't taken now, diabetes could cost Ontario $7 billion a year by 2020. (Source: CTV Health)
Survey Data Reveals Shocking 'Insulin Pump Postcode Lottery'
A comprehensive new survey of all 152 PCTs undertaken and published by the Medical Technology Group (MTG), backed by national diabetes support groups INPUT, the Juvenile Diabetes Research Foundation (JDRF), clinicians and leading cross-party MPs, has exposed major inequities in care for patients with diabetes across the country. The findings show that 17% of patients with type 1 diabetes in Blackburn with Darwen PCT benefit from insulin pump therapy, compared with only 0.4% in Luton, leaving tens of thousands of patients with type 1 diabetes without access to the right treatment from the NHS... (Source: Health News from Medical News Today)
PositiveID Corporation Agrees to Sell Its Health Link Personal Health Record Business for $1 Million
DELRAY BEACH, Fla., Sept. 8, 2010 (GLOBE NEWSWIRE) -- PositiveID Corporation ("PositiveID" or the "Company") (Nasdaq:PSID) announced today that it has agreed to sell its Health Link personal health record business for $1 million to Health Plexus, LLC. The Company will also retain the right to royalties on future Health Link revenues. Health Link is the Company's web-based personal health record (PHR), which is non-core to the Company's primary HealthID division. HealthID develops and markets unique medical devices, with a focus on diabetes management, and rapid medical testing products. (Source: Medical News (via PRIMEZONE))
Patient and Peri-operative Predictors of Morbidity and Mortality After Esophagectomy: American College of Surgeons National Surgical Quality Improvement Program (ACS-NSQIP), 2005?2008
Conclusions&nbsp;&nbsp;The major predictors of morbidity after an esophagectomy are the patient factors of diabetes, dyspnea, peripheral vascular disease, and cerebrovascular accident while the peri-operative factors are pre-operative international normalized ratio, contaminated wound classification, and American Society of Anesthesiologists class. Similarly, the major predictors of mortality are diabetes, dyspnea, and age for patient factors and contaminated wound classification for peri-operative factors. Content Type Journal ArticleDOI 10.1007/s11605-010-1328-2Authors Birat Dhungel, Division of General Surgery, Department of Surgery, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, L223A, Portland, OR 97239, USABrian S. Diggs, Division of General Surger...
Pancreatic Beta Cell Mass PET Imaging and Quantification with [11C]DTBZ and [18F]FP-(+)-DTBZ in Rodent Models of Diabetes
Conclusions&nbsp;&nbsp;PET imaging with [18F]FP-(+)-DTBZ provides a noninvasive means to quantify insulin-positive BCM and may prove valuable as a diagnostic tool in assessing treatments to maintain or restore BCM. Content Type Journal ArticleDOI 10.1007/s11307-010-0406-xAuthors Tarun Singhal, Department of Diagnostic Radiology, Yale University School of Medicine, New Haven, CT USAYu-Shin Ding, Department of Diagnostic Radiology, Yale University School of Medicine, New Haven, CT USADavid Weinzimmer, Department of Diagnostic Radiology, Yale University School of Medicine, New Haven, CT USAMarc D. Normandin, Department of Diagnostic Radiology, Yale University School of Medicine, New Haven, CT USADavid Labaree, Department of Diagnostic Radiology, Yale University School of Medicine,...<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
Elevated serum levels of interleukin-18 in patients with overt diabetic nephropathy: effects of miglitol
Conclusion&nbsp;&nbsp;Miglitol improved postprandial hyperglycemia and reduced serum IL-18 levels in patients with stage 3 diabetic nephropathy. Miglitol may therefore prevent atherosclerotic diseases and diabetic micro-vascular complications through decreasing glucose swings and/or the circulating IL-18 level. Content Type Journal ArticleDOI 10.1007/s10157-010-0343-7Authors Takashi Uzu, Department of Medicine, Shiga University of Medical Science, Otsu, Shiga 520-2192, JapanHiroki Yokoyama, Internal Medicine, Jiyugaoka Medical Clinic, Obihiro, Hokkaido JapanHirofumi Itoh, Internal Medicine, Jiyugaoka Medical Clinic, Obihiro, Hokkaido JapanDaisuke Koya, Division of Diabetes & Endocrinology, Department of Medicine, Kanazawa Medical University, Kahoku-gun, Ishikawa, JapanAtsushi ...
Investing In Prevention Can Save Costs As Well As Improve Health, Australia
Australia's largest disease prevention groups are calling on the returned Gillard government to ramp up investment in preventive health following the release today of a cost-effectiveness study demonstrating that enormous health gains and cost savings could be achieved. Commenting on the release of The Assessing Cost-Effectiveness in Prevention report, Professor Greg Johnson, spokesperson for the Australian Chronic Disease Prevention Alliance and Acting CEO of Diabetes Australia said the report was a timely reminder of the importance and value of investing in prevention... (Source: Health News from Medical News Today)
AHRQ Releases New Spanish Language Guides For Patients
HHS' Agency for Healthcare Research and Quality today released a series of free evidence-based guides designed to help Spanish speakers understand and compare the risks, benefits and side effects of treatments for eight health conditions. The guides provide valuable information that patients can use in talking with their clinicians. Half of the topics cover health issues specifically for women, including guides on controlling gestational diabetes during pregnancy, deciding to induce labor and comparing core needle biopsy to surgical biopsy for breast lesions... (Source: Health News from Medical News Today)
Short Sleepers At Higher Risk Of Type 2 Diabetes And Heart Disease
People who sleep less than six hours a night may be three times more likely to develop a condition which leads to diabetes and heart disease, according to researchers at the University of Warwick. A study by a team of researchers from Warwick Medical School and the State University of New York at Buffalo has found short sleep duration is associated with an elevated risk of a pre-diabetic state, known as incident-impaired fasting glycaemia (IFG). IFG means that your body isn't able to regulate glucose as efficiently as it should... (Source: Health News from Medical News Today)
Relevance of Serum Leptin and Leptin-Receptor Concentrations in Critically Ill Patients
The adipocyte-derived cytokine leptin was implicated to link inflammation and metabolic alterations. We investigated the potential role of leptin components in critically ill patients, because systemic inflammation, insulin resistance, and hyperglycemia are common features of critical illness. Upon admission to Medical Intensive Care Unit (ICU), free leptin and soluble leptin-receptor serum concentrations were determined in 137 critically ill patients (95 with sepsis, 42 without sepsis) and 26 healthy controls. Serum leptin or leptin-receptor did not differ between patients or controls and were independent of sepsis. However, serum leptin was closely associated with obesity and diabetes and clearly correlated with markers of metabolism and liver function. Leptin-receptor was an unfavourabl...<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
Chemical for keeping human pluripotent stem cells alive identified
Researchers have found that a chemically synthesized compound, blebbistatin, can help prevent cell death in human pluripotent stem cells. These cells are of interest to stem cell scientists working on finding therapies for spinal cord injuries, Parkinson's disease, burns, heart disease, diabetes, arthritis, and other ailments. Another advantage of using blebbistatin, say the researchers, is that no human- or animal-derived materials is needed for coating the culture surfaces. (Source: ScienceDaily Headlines)
A new role for insulin in cell survival, cell metabolism and stress response
Researchers have discovered a novel way in which insulin affects cell metabolism and cell survival. Surprisingly the insulin signaling pathway, which is involved in aging, diabetes and stress response, is active at a deeper level of cell activity than scientists expected. (Source: ScienceDaily Headlines)
Clinical Insights in Type 2 Diabetes
e-Newsletter: An e-Newsletter containing reviews of current literature and the latest information on the management of type 2 diabetes and cardiovascular disease (Source: Current CME-Certified Activities from Thomson Professional Postgraduate Services)
CME On-Demand
On-Demand: CME Video Vignettes, CME Interactive Case Studies, and more (Source: Current CME-Certified Activities from Thomson Professional Postgraduate Services)
More Than A Quarter Of All Acute Care Visits In US Now Made To Emergency Departments
Only 45 percent of the 354 million annual visits for acute care in the United States are made to patients' personal physicians, as Americans increasingly make busy emergency departments, specialists or outpatient care departments their first point of contact for treatment of new health problems or a flare up of a chronic condition like asthma or diabetes. The findings, which appear in the September edition of Health Affairs, do not bode well for the nation's already busy and frequently undermanned emergency rooms. While fewer than five percent of doctors across the U.S... (Source: Health News from Medical News Today)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
Health Care Reform: Will It Empower or Perplex Consumers?
Title: Health Care Reform: Will It Empower or Perplex Consumers?Category: Health NewsCreated: 9/7/2010 10:10:00 AMLast Editorial Review: 9/8/2010 (Source: MedicineNet Diabetes General)
P2.29 Progressions of (CTG) n expansions, muscular disability rating scale (MDRS), and abnormal glucose metabolism are age dependent in myotonic dystrophy type 1 (DM 1)
Conclusion: Both muscular involvement and AGM in DM1 might be progressed with age-dependent (CTG) n expansion. (Source: Neuromuscular Disorders)
P2.30 Oral fat loading study ? does specific hyperlipemia exist in myotonic dystrophy type 1?
Conclusion: Only FFA showed significant difference in the loading test between MD1 and controls. The lower level of FFA in MD1 could reflect effects of insulin itself. Our results suggested that MD1 had no specific postprandial hyperlipemia. Abnormality of lipid metabolism in MD1 should be clinically treated as secondary hyperlipemia. (Source: Neuromuscular Disorders)
The real war on drugs
Nature Medicine 16, 948 (2010). doi:10.1038/nm0910-948 Author: Cassandra Willyard The murder of ten aid workers, including an optometrist and a surgeon, in Afghanistan last month refocused the world's attention on the difficulties of providing health care in conflict zones. Beyond the dangers of delivering acute care such as surgery, dispensing medicines for chronic illnesses ranging from HIV to diabetes remains a challenge in areas affected by war. Cassandra Willyard looks at the lessons relief agencies have learned in recent years providing care amidst increasingly complex conflicts. (Source: Nature Medicine)
Risk factors for albuminuria, renal impairment in Type 2 diabetes revealed
Swedish researchers have found that older age, high systolic blood pressure, and high triglycerides increase the risk for albuminuria and renal impairment in patients with Type 2 diabetes. (Source: MedWire News - Diabetes)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
Methylprednisolone/prednisolone: Avascular necrosis of femoral heads and post-transplant diabetes mellitus: case report
(Source: Reactions)
Increased tissue leptin hormone level and mast cell count in skin tags: A possible role of adipoimmune in the growth of benign skin growths
Conclusion: This is the first report to demonstrate that tissue leptin may play a role in the pathogenesis of ST. The significant increase in the levels of leptin and mast cell count in ST may indicate a possible role of adipoimmune in the benign skin growths. (Source: Indian Journal of Dermatology, Venereology and Leprology)
Getting (the Most) Out of the Research Business: Interventions for Youth with T1DM
Abstract&nbsp;&nbsp;We review research on psychosocial interventions to improve outcomes for youth with type 1 diabetes mellitus. Specifically, we discuss individual- and small group?focused, family-focused, group-focused, and other interventions. After reviewing extant research in each area, we discuss how the current evidence base may be used to inform clinical practice. Finally, we conclude by discussing variations in effects of interventions on different outcomes (eg, glycemic control, family functioning) and how to consider this evidence when selecting treatments to transport into clinical settings. Content Type Journal ArticleDOI 10.1007/s11892-010-0142-2Authors Michael A. Harris, Pediatrics and Psychiatry, Division of Psychology, Child Development & Rehabilitation Cente...
Hypoglycemia in the Newborn
Abstract&nbsp;&nbsp;Hypoglycemia in a neonate is defined as blood sugar value below 40&nbsp;mg/dL. It is commonly associated with a variety of neonatal conditions like prematurity, intrauterine growth restriction and maternal diabetes. Screening for hypoglycemia in high-risk situations is recommended. Supervised breast-feeding may be an initial treatment option in asymptomatic hypoglycemia. However, symptomatic hypoglycemia should always be treated with a continuous infusion of parenteral dextrose. Neonates needing dextrose infusion rates above 12&nbsp;mg/kg/min should be investigated for a definite cause of hypoglycemia. Hypoglycemia has been linked to poor neuro-developmental outcome, and hence aggressive screening and treatment is recommended. Content Type Journal ArticleDOI 1...
Unmasking of undiagnosed pre-existing central diabetes insipidus after renal transplantation
We present a case of a patient with pre-existing and clinically unapparent CDI which was unmasked after renal transplantation. A 60&nbsp;year old woman with end-stage renal failure due to autosomal dominant polycystic kidney disease (ADPKD) underwent renal transplantation. She was noted to be markedly polyuric and polydipsic after the transplant. A fluid deprivation test was unequivocally positive for CDI, and desmopressin treatment resulted in immediate symptom relief. Neuroimaging revealed a midline defect in the region of the hypothalamus. She had a history of an intracerebral aneurysm that had ruptured, requiring extensive neurosurgery many years previously. This case demonstrates a rare instance of pre-existing but clinically unapparent CDI unmasked by renal transplantation. It ...<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
Simvastatin suppresses expression of angiogenic factors in the retinas of rats with streptozotocin-induced diabetes
Conclusions&nbsp;&nbsp;Simvastatin treatment led to suppression of superoxide formation and decreased expression of VEGF, angiopoietin 2 and erythropoietin in diabetic rat retinas. Content Type Journal ArticleDOI 10.1007/s00417-010-1496-5Authors Sul Gee Lee, Department of Ophthalmology, College of Medicine, Inje University, Busan, South KoreaJung Lim Kim, Department of Ophthalmology, College of Medicine, Inje University, Busan, South KoreaHan Kee Lee, Department of Ophthalmology, College of Medicine, Inje University, Busan, South KoreaGyu Won Ryu, Balgunoon Ophthalmic Clinic, Busan, South KoreaDae Young Hur, Department of Anatomy and Cell Biology, Inje University, Busan Paik Hospital, Busan, South KoreaIl Han Yun, Department of Ophthalmology, College of Medicine, Inje Universit...
Conditional ablation of Gsk-3? in islet beta cells results in expanded mass and resistance to fat feeding-induced diabetes in mice
Conclusions/interpretation&nbsp;&nbsp;These results are consistent with a mechanism whereby endogenous GSK-3? activity controls islet beta cell growth by feedback inhibition of the insulin receptor/PI3K/Akt signalling pathway. Content Type Journal ArticleDOI 10.1007/s00125-010-1882-xAuthors Y. Liu, Division of Endocrinology, Metabolism, and Lipid Research, Washington University School of Medicine, 660 S. Euclid Ave, Campus Box 8127, St Louis, MO 63110, USAK. Tanabe, Division of Endocrinology, Metabolism, and Lipid Research, Washington University School of Medicine, 660 S. Euclid Ave, Campus Box 8127, St Louis, MO 63110, USAD. Baronnier, Division of Endocrinology, Metabolism, and Lipid Research, Washington University School of Medicine, 660 S. Euclid Ave, Campus Box 8127, St Lo...
Brain cells determine obesity -- not lack of willpower: Study
(Monash University) An international study has discovered the reason why some people who eat a high-fat diet remain slim, yet others pile on the weight.The study, led in Australia by the Monash Obesity and Diabetes Institute at Monash University, found a high-fat diet causes brain cells to become insulated from the body preventing vital signals, which tell the body to stop eating and to burn energy, from reaching the brain efficiently. (Source: EurekAlert! - Medicine and Health)
Questioning the safety of certain 'healthful' plant-based antioxidants
(American Chemical Society) Scientists are calling for more research on the possibility that some supposedly healthful plant-based antioxidants -- including those renowned for their apparent ability to prevent cancer -- may actually aggravate or even cause cancer in some individuals. Their recommendation follows a study in which two such antioxidants -- quercetin and ferulic acid -- appeared to aggravate kidney cancer in severely diabetic laboratory rats. The study appears in ACS' bi-weekly Journal of Agricultural and Food Chemistry. (Source: EurekAlert! - Medicine and Health)
Cognition problems linked to physical ills
EDMONTON, Alberta, Sept. 7 (UPI) -- People with diabetes and high blood pressure who walk slowly or lose balance or say they're in bad health may have cognition issues, Canadian researchers say. Alberta - Canada - Edmonton - Hypertension - Health (Source: Health News - UPI.com)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
Short Sleepers at Higher Risk of Diabetes and Heart Disease
People who sleep less than six hours a night may be three times more likely to develop a condition which leads to diabetes and heart disease, according to researchers at the University of Warwick. (Source: Disabled World)
Diabetics have lower long-term CHD risk than nondiabetic AMI patients
Patients with Type 2 diabetes have a significantly lower 10-year incidence of coronary heart disease and cardiovascular mortality than nondiabetic patients with a first acute myocardial infarction. (Source: MedWire News - Diabetes)
Diabetes Resources Available
The Texas Department of State Health Services, Texas Diabetes Council, and the Central Texas Diabetes Coalition have developed two free resources to help physicians and health care providers provide optimal care to patients with diabetes. (Source: Blogged_Arteries)
Incentivising GPs cuts heart disease deaths and admissions
QOF monies iron out inequalities in access to healthcare as well as health outcomes, study showsRelated items from OnMedicaLicensing process for top selling diabetes drug under fireAntihypertensive drugs vary in heart attack riskRisk/benefit balance of alteplase shifts quicklyCare homes drug error rate raises concernsFake medicine warning hits cinemas (Source: OnMedica Latest News)
Ethnic differences in dissatisfaction with sexual life in patients with type 2 diabetes in a Swedish town
Conclusions: The findings demonstrate that almost half of participants were dissatisfied with their sexual life and highlight the importance of sexual life to people with type 2 diabetes. This factor should not be ignored in clinical evaluations. Moreover, the findings demonstrate that it is possible to include questions on sexual life in investigations of patients with type 2 diabetes and even in other health-related, questionnaire studies, despite the sensitivity of the issue of sexuality. (Source: BMC Public Health - Latest articles)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
Occupational cataracts and lens opacities in interventional cardiology (O'CLOC study): are X-Rays Involved?
DiscussionThis epidemiological study will provide further evidence about the potential risk of radiation-induced cataracts at low doses and contribute to cardiologists' awareness of the importance of radiation protection.Trial Registration: NCT01061463 (Source: BMC Public Health - Latest articles)
The effectiveness of interventions to change six health behaviours: a review of reviews
Conclusions: Despite limitations of the review of reviews approach, it is encouraging that there are interventions that are effective in achieving behavioural change. Further emphasis in both primary studies and secondary analysis (e.g. systematic reviews) should be placed on assessing the differential effectiveness of interventions across different population subgroups to ensure that health inequalities are addressed. (Source: BMC Public Health - Latest articles)
Report: Long-Term Weight Loss Could Bring Harmful Health Effects
Long-term weight loss may release into the blood industrial pollutants linked to illnesses like diabetes, hypertension and rheumatoid arthritis, researchers said on Tuesday. These compounds are normally stored in fatty tissues, but when fat breaks down... (Source: OrlandoSentinel: Medical Research)
National Service Framework for children, young people and maternity services: Diabetes type 1 in childhood
Source: Department of Health (DH) Area: News The Department of Health has issued an exemplar which describes a care pathway for a child with Type 1 diabetes. &nbsp; The National Service Framework (NSF) for Children, Young People and Maternity Services has been published alongside supporting material, which includes a series of exemplar patient journeys. While it is not the role of the NSF or the exemplars to provide detailed clinical discussion on individual childhood conditions, exemplars illustrate some of the key themes in the NSF. &nbsp; Please see link below for the exemplar on type 1 diabetes in childhood. (Source: NeLM - News)
Antidepressant medication use, weight gain and risk of type 2 diabetes mellitus
Source: Diabetes Care Area: News According to research published early online in Diabetes Care, continuing use of antidepressant medication is associated with an increased relative risk of type 2 diabetes, although the elevation in absolute risk was modest. &nbsp; Researchers in this study sought to evaluate antidepressant medication use as a risk factor for type 2 diabetes and weight gain. A series of 3 nested studies within a prospective cohort of 151,347 working-aged men and women including 9197 participants with continuing antidepressant medication, 224 with severe depression, and 851 with incident type 2 diabetes mellitus during a mean follow-up of 4.8 years were evaluated. .&nbsp;Study 1 examined differences in antidepressant medication use between 851 incident type 2 diabetes...<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
Rapid Response to Sorafenib in Metastatic Medullary Thyroid Carcinoma
Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0030-1262836AbstractObjective: To investigate the efficacy of sorafenib in progressive metastatic Medullary Thyroid Carcinoma (MTC), for which there is currently no effective treatment.[...]© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournal:Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes)
Impaired Glucose Tolerance in Obese white Children and Adolescents: Three to Five year follow-up in Untreated Patients
Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0030-1263150AbstractObjective: Impaired glucose tolerance (IGT) is a predictor of type 2 diabetes in adults. However, the converting rate from IGT to diabetes is largely unknown in obese children.[...]© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournal:Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes)
Diet Dependence of Diabetes in the New Zealand Obese (NZO) Mouse: Total Fat, But not Fat Quality or Sucrose Accelerates and Aggravates Diabetes
Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0030-1263127AbstractBackground: Obesity and diabetes in mice can be modified by dietary variables. Here we systematically analysed the effect of the sucrose and fat content and of the fat quality in New Zealand Obese mice, a mouse model of the metabolic syndrome.[...]© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournal:Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes)
Stanniocalcin 1 Induction by Thyroid Hormone Depends on Thyroid Hormone Receptor ? and Phosphatidylinositol 3-kinase Activation
Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0030-1262860AbstractContext: Thyroid hormone (TH) mediated changes in gene expression were thought to be primarily initiated by the nuclear TH receptor (TR) binding to a thyroid hormone response element in the promoter of target genes. A recently described extranuclear mechanism of TH action consists of the association of TH-liganded TR&#946; with phosphatidylinositol 3-kinase (PI3K) in the cytosol and subsequent activation of the PI3K pathway.[...]© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournal:Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes)
Serum Resistin Concentrations are Higher in Human Obesity but Independent from Insulin Resistance
Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0030-1263111AbstractAlthough obesity may be linked to resistin, the role of resistin in humans is still controversial. Conflicting results of the associations between resistin and BMI and measures of insulin resistance were reported. In view of the yet unexplained role of resistin in human obesity, the aim of this study was to examine correlations between serum resistin concentrations and the degree of human obesity and insulin sensitivity. For this purpose, we investigated 2 homogenous groups of obese and non obese humans, in whom the presence of obesity was the solely differentiating factor. The WHO definition of obesity was used. Study group consisted of 136 obese subjects (75 women and 61 men) and 48 non-obese controls (31 women, 17 men) aged ...<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
Demographic Factors and the Presence of Comorbidities do not Promote Early Detection of Cushing's Disease and Acromegaly
Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0030-1263104AbstractObjective: The aim of the study was to analyze the time-to-diagnosis interval in patients with Cushing's disease (CD) and acromegaly (AC), to assess factors that promote early disease detection and to investigate the medical fields diagnosing the pathologies.[...]© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournal:Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes)
Induction of Pancreatic Phenotypes in Central Nervous System Derived Pluripotential Progenitor Cells
In this study, we explored whether these RSCs could also be influenced to acquire properties characteristic of the pancreas. To this end, RSCs in culture were exposed to media conditioned by rat islet tumor cells and media containing Exendin-4 and nicotinamide since both have been shown to induce pancreatic phenotypes in embryonic stem cells. Lastly, an expression construct for pdx-1 was introduced into RSCs. The expression of pancreatic markers was analyzed using RT-PRC and immunocytochemistry. When RSCs were exposed to rat islet tumor cell conditioned media and media containing Exendin-4 and nicotinamide, the expression of pdx-1, insulin and somatostatin were observed. They also acquired a spherical shape typical of pancreatic cells in culture. Under these varied conditions, transcriptio...
Consumption of rapeseed honey leads to higher serum fructose levels compared with analogue glucose/fructose solutions
Consumption of rapeseed honey leads to higher serum fructose levels compared with analogue glucose&#47;fructose solutions European Journal of Clinical Nutrition advance online publication, September 8, 2010. doi:10.1038/ejcn.2010.186 Authors: K M&#252;nstedt, M B&#246;hme, A Hauenschild & I Hrgovic (Source: European Journal of Clinical Nutrition)
A trans-acting locus regulates an anti-viral expression network and type 1 diabetes risk
Authors: Matthias Heinig, Enrico Petretto, Chris Wallace, Leonardo Bottolo, Maxime Rotival, Han Lu, Yoyo Li, Rizwan Sarwar, Sarah R. Langley, Anja Bauerfeind, Oliver Hummel, Young-Ae Lee, Svetlana Paskas, Carola Rintisch, Kathrin Saar, Jason Cooper, Rachel Buchan, Elizabeth E. Gray, Jason G. Cyster, Jeanette Erdmann, Christian Hengstenberg, Seraya Maouche, Willem H. Ouwehand, Catherine M. Rice, Nilesh J. Samani, Heribert Schunkert, Alison H. Goodall, Herbert Schulz, Helge G. Roider, Martin Vingron, Stefan Blankenberg, Thomas M&#252;nzel, Tanja Zeller, Silke Szymczak, Andreas Ziegler, Laurence Tiret, Deborah J. Smyth, Michal Pravenec, Timothy J. Aitman, Francois Cambien, David Clayton, John A. Todd, Norbert Hubner & Stuart A. Cook Combined analyses of gene networks and DNA sequence vari...
Health 2.0 Developer Challenge: Project HealthDesign Challenge
Deadline: September 15, 2010 Program Area: Pioneer Purpose: In its first round, from 2006 to 2008, Project HealthDesign supported nine teams to design and build prototype applications that could be run on top of personal health data. Now, the Robert Wood Johnson Foundation&#39;s Pioneer Portfolio and California HealthCare Foundation seek designers and innovators to translate one of these nine prototypes into working applications that run on smartphones, tablets or web platforms. A key tenet of Project HealthDesign is the separation of the service used to maintain the data in someone&rsquo;s personal health record (PHR) from the many apps that could be used to collect, display, analyze or otherwise turn that data into actions that would lead to better health. The nine teams were ...<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
Prevention of diabetic nephropathy in Ins2{+}/-AkitaJ mice by the mitochondria-targeted therapy Mito Q.
Mitochondrial production of reactive oxygen species is thought to be associated with the cellular damage resulting from chronic exposure to high glucose in long term diabetic patients. We hypothesized that a mitochondria-targeted antioxidant would prevent kidney damage in the Ins2&#x002B;/-AkitaJ mouse model (Akita mice) of type 1 diabetes. To test this we orally administered a mitochondria-targeted ubiquinone (MitoQ) over a 12 week period and assessed tubular and glomerular function. Fibrosis and pro-fibrotic signaling pathways were determined by immunohistochemical analysis, and mitochondria were isolated from the kidney for functional assessment. MitoQ treatment improved tubular and glomerular function in the Ins2&#x002B;/-AkitaJ mice. MitoQ did not have a significant effect on plasma c...
Prevention of diabetic nephropathy in Ins2+/-AkitaJ mice by the mitochondria-targeted therapy Mito Q.
Authors: Chacko B, Reily C, Srivastava A, Johnson MS, Ulasova E, Agarwal A, Zinn K, Murphy MP, Kalyanaraman B, Darley-Usmar V Mitochondrial production of reactive oxygen species is thought to be associated with the cellular damage resulting from chronic exposure to high glucose in long term diabetic patients. We hypothesized that a mitochondria-targeted antioxidant would prevent kidney damage in the Ins2+/-AkitaJ mouse model (Akita mice) of type 1 diabetes. To test this we orally administered a mitochondria-targeted ubiquinone (MitoQ) over a 12 week period and assessed tubular and glomerular function. Fibrosis and pro-fibrotic signaling pathways were determined by immunohistochemical analysis, and mitochondria were isolated from the kidney for functional assessment. MitoQ treatment imp...
Animal-Based Low-Carbohydrate Diet Linked to Higher All-Cause Mortality Rates
An animal-based low-carbohydrate diet was associated with higher all-cause mortality, but a vegetable-based low-carbohydrate diet was linked with lower all-cause and cardiovascular disease mortality. Medscape Medical News (Source: Medscape Today Headlines)
US Patients Going Straight To Emergency Department, Bypassing Personal Physicians
Every wondered why emergency departments in the USA are so crowded? The answer seems to be in people's changing behaviors over the last few years. Today, only 45% of the 354 million yearly visits for acute care in the USA are made to the patient's personal doctor, while an enormous number are going straight to emergency departments, seeing specialists, or turning up at outpatient care departments as their first point of call for treatment for new health problems, episodes, or a flare-up of a chronic health condition, such as diabetes or asthma... (Source: Health News from Medical News Today)
Short sleepers at higher risk of type 2 diabetes and heart disease, study finds
People who sleep less than six hours a night may be three times more likely to develop a condition which leads to diabetes and heart disease, according to researchers. (Source: ScienceDaily Headlines)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
Paraneoplastic neurological syndrome in a patient with gastric cancer
Abstract&nbsp;&nbsp;Paraneoplastic neurological syndromes (PNSs) are a heterogeneous group of neurological disorders caused by immunemediated mechanisms. The incidence of PNS is much less than 1% for solid tumors, except for small-cell lung cancer and thymoma. We report a rare case of gastric cancer that presented with primary clinical findings of PNS. The patient was a 63-year-old woman who was admitted for worsening neuropathy. Laboratory and neurological tests excluded a nutritional deficit, diabetes mellitus, and connective tissue disease as causes of her neuropathy. Computed tomography (CT) of the abdomen, positron emission tomography (PET)-CT, and endoscopy of the stomach revealed gastric cancer with lymph node swelling. Distal gastrectomy was performed and pathological and imm...
A New Role for Insulin in Cell Survival, Cell Metabolism and Stress Response
September 7, 2010 (EurekAlert) - Researchers at the Buck Institute for Age Research have discovered a novel way in which insulin affects cell metabolism and cell survival. Surprisingly the insulin signaling pathway, which is involved in aging, diabetes and stress response, is active at a deeper level of cell activity than scientists expected. The study appears in the September 8th issue of Cell Metabolism. read more (Source: Diabetes News from dLife.com)
Guidelines for Glycemic Control and Individualized Targets [Letters]
(Source: JAMA)
Guidelines for Glycemic Control and Individualized Targets--Reply [Letters]
(Source: JAMA)
Reducing the Risk of CVD in Patients with Periodontitis
The association between periodontitis and other chronic diseases, such as cardiovascular disease and type 2 diabetes, could be related to systemic inflammation initiated by a local inflammatory challenge. Nature Reviews Cardiology (Source: Medscape Diabetes Headlines)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
NIH Study Shows How Insulin Stimulates Fat Cells to Take in Glucose
Source: National Institute of Child Health and Human Development, National Institute of Diabetes and Digestive and Kidney Diseases - Related MedlinePlus Page: Diabetes (Source: MedlinePlus Health News)
It's Not Your Fault - Blame Biology!
I turn on the TV and find a commercial informing me that I should Blame Biology rather than french fries for an outbreak of acne. It is true that biologic factors involved in acne include excess sebum production caused by increased hormones, outlet obstruction of sebaceous follicles and inflammation.&nbsp; Further, research has shown that greasy foods and chocolates won't worsen acne. However, excessive manipulation and rubbing, hair gels, medications, stress and certain foods such as refined sugars and starches will increase oil production and probably the pimple population. In other words, you do have some control over your complexion.This Blame Biology message is not new, nor is it limited to dermatology. We are always looking for something or someone to blame; allowing us to shift resp...
Natural killer cells in NOD.NK1.1 mice acquire cytolytic function during viral infection and provide protection against cytomegalovirus [Immunology]
Resting natural killer (NK) cells in nonobese diabetic (NOD) mice have impaired immune functions compared with NK cells from other... (Source: Proceedings of the National Academy of Sciences)
Benign Prostatic Hyperplasia and Male Lower Urinary Tract Symptoms: Epidemiology and Risk Factors
Abstract&nbsp;&nbsp;The epidemiology of benign prostatic hyperplasia (BPH) and male lower urinary tract symptoms (LUTS) has evolved considerably during the past several years. The term LUTS describes a distinct phenotype and allows for a broad epidemiologic description of urinary symptoms at a population level. Although it is becoming the preferred term for studying urinary symptoms in populations, LUTS remains interconnected with BPH in the literature. The incidence and prevalence of BPH and LUTS are increasing rapidly as the US population ages. BPH and LUTS are associated with serious medical morbidities, an increased risk of falls, depression, diminished health-related quality of life, and billions of dollars in annual health care costs. Although age and genetics play important ro...
Preconception Counseling for Adolescent Females with Type 1 Diabetes: The READY-Girls Program
Content Type Journal ArticleDOI 10.1007/s11892-010-0144-0Authors Korey K. Hood, Center for Treatment Adherence, Division of Behavioral Medicine and Clinical Psychology, Cincinnati Children?s Hospital Medical Center, Department of Pediatrics, University of Cincinnati College of Medicine, 3333 Burnet Avenue, MLC 7039, Cincinnati, OH 45229, USA Journal Current Diabetes ReportsOnline ISSN 1539-0829Print ISSN 1534-4827 (Source: Current Diabetes Reports)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
The Genetics of Insulin Resistance: Where?s Waldo?
We present alternative views that may partly explain the apparent dearth of insulin resistance loci contributing to genetic susceptibility to type 2 diabetes, rather than focus on traditional issues such as study design and sampling, which have been addressed elsewhere. Content Type Journal ArticleDOI 10.1007/s11892-010-0143-1Authors Richard M. Watanabe, Departments of Preventive Medicine and Physiology & Biophysics, Keck School of Medicine of USC, 1540 Alcazar Street, CHP-220, Los Angeles, CA 90089-9011, USA Journal Current Diabetes ReportsOnline ISSN 1539-0829Print ISSN 1534-4827 (Source: Current Diabetes Reports)
Nuts and Berries for Heart Health
Abstract&nbsp;&nbsp;Nuts are nutrient-dense foods with complex matrices rich in unsaturated fatty acids and other bioactive compounds, such as L-arginine, fiber, minerals, tocopherols, phytosterols, and polyphenols. By virtue of their unique composition, nuts are likely to beneficially impact heart health. Epidemiologic studies have associated nut consumption with a reduced incidence of coronary heart disease in both genders and diabetes in women. Limited evidence also suggests beneficial effects on hypertension and inflammation. Interventional studies consistently show that nut intake has a cholesterol-lowering effect and there is emerging evidence of beneficial effects on oxidative stress, inflammation, and vascular reactivity. Blood pressure, visceral adiposity, and glycemic contr...
Early and Mid-term Outcomes of Single-Stage Laparoscopic Sleeve Gastrectomy
Conclusions&nbsp;&nbsp;LSG provides satisfactory weight loss and resolution of comorbidities in the short- and medium-term with inferior, though acceptable, results in the super obese. Content Type Journal ArticleDOI 10.1007/s11695-010-0267-zAuthors Sanket Srinivasa, Department of Surgery, South Auckland Clinical School, Middlemore Hospital, University of Auckland, Auckland, New ZealandLaura S Hill, Department of Surgery, South Auckland Clinical School, Middlemore Hospital, University of Auckland, Auckland, New ZealandTarik Sammour, Department of Surgery, South Auckland Clinical School, Middlemore Hospital, University of Auckland, Auckland, New ZealandAndrew G Hill, Department of Surgery, South Auckland Clinical School, Middlemore Hospital, University of Auckland, Auckland, New...
Protein Intake, Body Composition, and Protein Status Following Bariatric Surgery
Conclusions&nbsp;&nbsp;Our study underscores the value of protein supplementation for the achievement of the recommended daily protein intake in the bariatric patient. However, our data does not help to define a PI goal as critical in determining the FFM and protein status changes following LGBP or LSG. Content Type Journal ArticleDOI 10.1007/s11695-010-0268-yAuthors Alba Andreu, Obesity Unit, Endocrinology and Diabetes Department, Hospital Clínic Universitari, Villarroel 170, 08036 Barcelona, SpainVioleta Moizé, Obesity Unit, Endocrinology and Diabetes Department, Hospital Clínic Universitari, Villarroel 170, 08036 Barcelona, SpainLucía Rodríguez, Obesity Unit, Endocrinology and Diabetes Department, Hospital Clínic Universitari, Villarroel 170, 08036 Barcelona, SpainLil...


of young people who died suddenly has been on the rise. While the risk of atherosclerosis or the hardening of arteries can certainly carry over from childhood to adulthood, it is still no concrete evidence to link these sudden deaths of young people with childhood atherosclerosis unless their postmortem findings are made known.

Although there is an increasing number of children suffer from these and other risk factors for cardiovascular disease, testing for future heart conditions is still not standard practice. Currently, there is also no need to routinely screen lipid levels in all children.

If the lipid levels are normal, no specific treatment is needed. Nevertheless, maintaining healthy lifestyle is very important. This includes attention paid to healthy diet, regular exercise, and good weight management.

Selectively those with and those at risk are screened and statins have been used to treat children with familial hypercholesterolemia. Statins are drugs that lower bad cholesterol levels by limiting the amount of cholesterol the body can make.

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